Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer

Jose M. Silva; Jose M. Garcia; Rocio Gonzalez; Gemma Dominguez; Eugenia Jareño; Jose Palacios; Fatima Navarro; Mariano Provencia; Pilar España; Felix Bonilla

doi:10.1016/S0304-3835(99)00017-8

Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer

Jose M. Silva
, Jose M. Garcia
, Rocio Gonzalez
, Gemma Dominguez
, Eugenia Jareño
, Jose Palacios
, Fatima Navarro
, Mariano Provencia
, Pilar España
, Felix Bonilla

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified. Copyright (C) 1999 Elsevier Science S.A.

Original language	English
Pages (from-to)	209-215
Number of pages	7
Journal	Cancer Letters
Volume	138
Issue number	1-2
DOIs	https://doi.org/10.1016/S0304-3835(99)00017-8
State	Published - 26 Apr 1999
Externally published	Yes

Keywords

17q21 region
Allele frequencies
Breast cancer
Genotypes
LOH

Access to Document

10.1016/S0304-3835(99)00017-8

Cite this

@article{377c6704694c40159900002ef09a55f5,

title = "Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer",

abstract = "This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified. Copyright (C) 1999 Elsevier Science S.A.",

keywords = "17q21 region, Allele frequencies, Breast cancer, Genotypes, LOH",

author = "Silva, \{Jose M.\} and Garcia, \{Jose M.\} and Rocio Gonzalez and Gemma Dominguez and Eugenia Jare{\~n}o and Jose Palacios and Fatima Navarro and Mariano Provencia and Pilar Espa{\~n}a and Felix Bonilla",

note = "Funding Information: This work was supported by a grant from the Fundaci{\'o}n Central Hispano. ",

year = "1999",

month = apr,

day = "26",

doi = "10.1016/S0304-3835(99)00017-8",

language = "English",

volume = "138",

pages = "209--215",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1-2",

}

TY - JOUR

T1 - Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer

AU - Silva, Jose M.

AU - Garcia, Jose M.

AU - Gonzalez, Rocio

AU - Dominguez, Gemma

AU - Jareño, Eugenia

AU - Palacios, Jose

AU - Navarro, Fatima

AU - Provencia, Mariano

AU - España, Pilar

AU - Bonilla, Felix

N1 - Funding Information: This work was supported by a grant from the Fundación Central Hispano.

PY - 1999/4/26

Y1 - 1999/4/26

N2 - This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified. Copyright (C) 1999 Elsevier Science S.A.

AB - This study was carried out to evaluate the frequencies of alleles of four polymorphic markers in the 17q21 region in breast cancer patients, and their relation to seven pathological parameters. One hundred and sixty-four patients with breast cancer and 102 controls were analyzed. D17S856, D17S855, D17S1323 and D17S1327 polymorphic markers were studied, and used to investigate loss of heterozygosity in this region. The frequencies of alleles at marker D17S856 differed significantly in breast cancer patients and controls, and were related to histologic features considered to indicate a poor prognosis. When present, the pathophenotype of tumors associated with LOH in the 17q21 region is modified. Copyright (C) 1999 Elsevier Science S.A.

KW - 17q21 region

KW - Allele frequencies

KW - Breast cancer

KW - Genotypes

KW - LOH

UR - https://www.scopus.com/pages/publications/0033606082

U2 - 10.1016/S0304-3835(99)00017-8

DO - 10.1016/S0304-3835(99)00017-8

M3 - Article

C2 - 10378795

AN - SCOPUS:0033606082

SN - 0304-3835

VL - 138

SP - 209

EP - 215

JO - Cancer Letters

JF - Cancer Letters

IS - 1-2

ER -

Abnormal frequencies of alleles in polymorphic markers of the 17q21 region is associated with breast cancer

Abstract

Keywords

Access to Document

Fingerprint

Cite this