Abstract

The Kruppel-like transcription factor zinc finger protein (ZNF)217 (mouse homolog ZFP217) contributes to tumorigenesis by dysregulating gene expression programs. The newly discovered molecular function of ZFP217 in controlling N6-methyladenosine (m6A) deposition in embryonic stem cells (ESCs) sheds new light on the role of this transcription factor in tumor development.

Original languageEnglish
Pages (from-to)986-988
Number of pages3
JournalTrends in Biochemical Sciences
Volume41
Issue number12
DOIs
StatePublished - 1 Dec 2016

Keywords

  • N6-methyladenosine
  • RNA methylation
  • ZNF217
  • cancer
  • stem cell

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