Zero contrast retrograde chronic total occlusions percutaneous coronary intervention: A case series

Raja Hatem, Matthew T. Finn, Robert F. Riley, Moses Mathur, William L. Lombardi, Ziad A. Ali, Dimitri Karmpaliotis

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Introduction Percutaneous coronary intervention (PCI) in patients with advanced chronic kidney disease (CKD) is associated with a high risk of contrast-induced nephropathy and resulting progression of CKD to need for renal replacement therapy. Chronic total occlusions (CTO) PCI is increasingly utilized in the treatment of refractory stable angina and ischaemic heart failure. Recent studies have described the feasibility of 'minimal' or 'zero' contrast PCI by employing intravascular imaging and intra-coronary physiology to guide successful stent implantation with resolution of ischaemia. We extended these techniques to CTO lesions via the retrograde approach. Case presentation Two patients with estimated glomerular filtration rate <_15 mL/min who presented with angina symptoms and had subsequent positive stress tests were referred for CTO-PCI. The patients had diagnostic angiography with minimal contrast. After a recovery period, the patients underwent successful retrograde zero contrast CTO-PCI with the use of adjunctive intravascular ultrasound imaging. Discussion The described reports are the first two successful attempts at zero contrast retrograde procedures and demonstrate the feasibility of imaging and physiology-guided retrograde PCI without contrast administration in two patients with significant coronary artery disease requiring intervention. When indicated, zero contrast PCI offers the ability to treat obstructive coronary disease without worsening renal function in patients with severe CKD.

Original languageEnglish
Article numberyty036
JournalEuropean Heart Journal - Case Reports
Issue number2
StatePublished - 1 Jun 2018
Externally publishedYes


  • Case series
  • Chronic kidney disease
  • Chronic occlusion
  • Contrast-induced nephropathy
  • Percutaneous coronary intervention
  • Retrograde


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