Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion

Hui Zhang; Alexander Von Gise; Qiaozhen Liu; Tianyuan Hu; Xueying Tian; Lingjuan He; Wenjuan Pu; Xiuzhen Huang; Liang He; Chen Leng Cai; Fernando D. Camargo; William T. Pu; Bin Zhou

doi:10.1074/jbc.M114.554584

Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion

Hui Zhang
, Alexander Von Gise
, Qiaozhen Liu
, Tianyuan Hu
, Xueying Tian
, Lingjuan He
, Wenjuan Pu
, Xiuzhen Huang
, Liang He
, Chen Leng Cai
, Fernando D. Camargo
, William T. Pu
, Bin Zhou

Research output: Contribution to journal › Article › peer-review

148 Scopus citations

Abstract

Background: YAP1 regulates EMT and cell proliferation. Results: Deletion of YAP1 in endocardial cells reduces EMT of endocardial cells, and causes cardiac cushion defect. Conclusion: YAP1 is required for cardiac cushion development. Significance: This is the first in vivo genetic evidence for YAP1 function in EMT.

Original language	English
Pages (from-to)	18681-18692
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	27
DOIs	https://doi.org/10.1074/jbc.M114.554584
State	Published - 4 Jul 2014

Access to Document

10.1074/jbc.M114.554584

Cite this

@article{c7304b83d5094108aa2ca3f6722ad6a6,

title = "Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion",

abstract = "Background: YAP1 regulates EMT and cell proliferation. Results: Deletion of YAP1 in endocardial cells reduces EMT of endocardial cells, and causes cardiac cushion defect. Conclusion: YAP1 is required for cardiac cushion development. Significance: This is the first in vivo genetic evidence for YAP1 function in EMT.",

author = "Hui Zhang and \{Von Gise\}, Alexander and Qiaozhen Liu and Tianyuan Hu and Xueying Tian and Lingjuan He and Wenjuan Pu and Xiuzhen Huang and Liang He and Cai, \{Chen Leng\} and Camargo, \{Fernando D.\} and Pu, \{William T.\} and Bin Zhou",

year = "2014",

month = jul,

day = "4",

doi = "10.1074/jbc.M114.554584",

language = "English",

volume = "289",

pages = "18681--18692",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.",

number = "27",

}

TY - JOUR

T1 - Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion

AU - Zhang, Hui

AU - Von Gise, Alexander

AU - Liu, Qiaozhen

AU - Hu, Tianyuan

AU - Tian, Xueying

AU - He, Lingjuan

AU - Pu, Wenjuan

AU - Huang, Xiuzhen

AU - He, Liang

AU - Cai, Chen Leng

AU - Camargo, Fernando D.

AU - Pu, William T.

AU - Zhou, Bin

PY - 2014/7/4

Y1 - 2014/7/4

N2 - Background: YAP1 regulates EMT and cell proliferation. Results: Deletion of YAP1 in endocardial cells reduces EMT of endocardial cells, and causes cardiac cushion defect. Conclusion: YAP1 is required for cardiac cushion development. Significance: This is the first in vivo genetic evidence for YAP1 function in EMT.

AB - Background: YAP1 regulates EMT and cell proliferation. Results: Deletion of YAP1 in endocardial cells reduces EMT of endocardial cells, and causes cardiac cushion defect. Conclusion: YAP1 is required for cardiac cushion development. Significance: This is the first in vivo genetic evidence for YAP1 function in EMT.

UR - https://www.scopus.com/pages/publications/84903840927

U2 - 10.1074/jbc.M114.554584

DO - 10.1074/jbc.M114.554584

M3 - Article

C2 - 24831012

AN - SCOPUS:84903840927

SN - 0021-9258

VL - 289

SP - 18681

EP - 18692

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 27

ER -

Yap1 Is required for endothelial to mesenchymal transition of the atrioventricular cushion

Abstract

Access to Document

Fingerprint

Cite this