XPC: Going where no DNA damage sensor has gone before

Leah Nemzow, Abigail Lubin, Ling Zhang, Feng Gong

Research output: Contribution to journalReview articlepeer-review

27 Scopus citations


XPC has long been considered instrumental in DNA damage recognition during global genome nucleotide excision repair (GG-NER). While this recognition is crucial for organismal health and survival, as XPC's recognition of lesions stimulates global genomic repair, more recent lines of research have uncovered many new non-canonical pathways in which XPC plays a role, such as base excision repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and cellular viability. Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably. Indeed, our understanding appears to barely scratch the surface of the incredible potential influence of XPC on maintaining proper cellular function. Here, we first review the canonical role of XPC in lesion recognition and then explore the new world of XPC function.

Original languageEnglish
Pages (from-to)19-27
Number of pages9
JournalDNA Repair
StatePublished - 2015
Externally publishedYes


  • BER
  • DNA repair
  • GG-NER
  • Nucleotide excision repair
  • Rad4
  • XPC


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