Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography: Implications for hyperpolarized Xenon MRI

M. Liotti; C. C. Martin; J. H. Gao; J. W. Roby; H. S. Mayberg; F. Zamarripa; P. A. Jerabek; P. T. Fox

doi:10.1002/jmri.1880070424

Xenon effects on regional cerebral blood flow assessed by ¹⁵O-H₂O positron emission tomography: Implications for hyperpolarized Xenon MRI

M. Liotti, C. C. Martin, J. H. Gao, J. W. Roby, H. S. Mayberg, F. Zamarripa, P. A. Jerabek, P. T. Fox

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Subjective and physiologic effects of 33% inhaled Xe were measured with ¹⁵O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air-breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.

Original language	English
Pages (from-to)	761-764
Number of pages	4
Journal	Journal of Magnetic Resonance Imaging
Volume	7
Issue number	4
DOIs	https://doi.org/10.1002/jmri.1880070424
State	Published - 1997
Externally published	Yes

Keywords

Hyperpolarized Xe-MRI
Positron emission tomography
Xenon

Access to Document

10.1002/jmri.1880070424

Cite this

@article{c85894cc9aec4394b68a8dd9f39ad753,

title = "Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography: Implications for hyperpolarized Xenon MRI",

abstract = "Subjective and physiologic effects of 33% inhaled Xe were measured with 15O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air-breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.",

keywords = "Hyperpolarized Xe-MRI, Positron emission tomography, Xenon",

author = "M. Liotti and Martin, {C. C.} and Gao, {J. H.} and Roby, {J. W.} and Mayberg, {H. S.} and F. Zamarripa and Jerabek, {P. A.} and Fox, {P. T.}",

year = "1997",

doi = "10.1002/jmri.1880070424",

language = "English",

volume = "7",

pages = "761--764",

journal = "Journal of Magnetic Resonance Imaging",

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publisher = "John Wiley & Sons Inc.",

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TY - JOUR

T1 - Xenon effects on regional cerebral blood flow assessed by 15O-H2O positron emission tomography

T2 - Implications for hyperpolarized Xenon MRI

AU - Liotti, M.

AU - Martin, C. C.

AU - Gao, J. H.

AU - Roby, J. W.

AU - Mayberg, H. S.

AU - Zamarripa, F.

AU - Jerabek, P. A.

AU - Fox, P. T.

PY - 1997

Y1 - 1997

N2 - Subjective and physiologic effects of 33% inhaled Xe were measured with 15O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air-breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.

AB - Subjective and physiologic effects of 33% inhaled Xe were measured with 15O-water positron emission tomography (PET) in 3 subjects at rest and during visual stimulation. The procedure was well tolerated. Robust functional activations of the visual cortex were obtained after xenon (Xe) inhalation as well as air breathing. However, Xe inhalation was followed by smaller size, but significant decreases of regional cerebral blood flow (rCBF) in visual cortex relative to the air-breathing baseline, both during visual stimulation and at rest. No such decreases were found in other sensory or motor regions.

KW - Hyperpolarized Xe-MRI

KW - Positron emission tomography

KW - Xenon

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DO - 10.1002/jmri.1880070424

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