XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Christina Piperi; Christos Adamopoulos; Athanasios G. Papavassiliou

doi:10.1016/j.tem.2016.01.001

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Christina Piperi
, Christos Adamopoulos
, Athanasios G. Papavassiliou

Research output: Contribution to journal › Short survey › peer-review

80 Scopus citations

Abstract

X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.

Original language	English
Pages (from-to)	119-122
Number of pages	4
Journal	Trends in Endocrinology and Metabolism
Volume	27
Issue number	3
DOIs	https://doi.org/10.1016/j.tem.2016.01.001
State	Published - 1 Mar 2016
Externally published	Yes

Keywords

Glucose
Lipogenesis
Metabolic diseases
Unfolded protein response
X-box binding protein 1

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10.1016/j.tem.2016.01.001

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title = "XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism",

abstract = "X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.",

keywords = "Glucose, Lipogenesis, Metabolic diseases, Unfolded protein response, X-box binding protein 1",

author = "Christina Piperi and Christos Adamopoulos and Papavassiliou, \{Athanasios G.\}",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd.",

year = "2016",

month = mar,

day = "1",

doi = "10.1016/j.tem.2016.01.001",

language = "English",

volume = "27",

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journal = "Trends in Endocrinology and Metabolism",

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TY - JOUR

T1 - XBP1

T2 - A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

AU - Piperi, Christina

AU - Adamopoulos, Christos

AU - Papavassiliou, Athanasios G.

PY - 2016/3/1

Y1 - 2016/3/1

N2 - X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.

AB - X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.

KW - Glucose

KW - Lipogenesis

KW - Metabolic diseases

KW - Unfolded protein response

KW - X-box binding protein 1

UR - https://www.scopus.com/pages/publications/84958117802

U2 - 10.1016/j.tem.2016.01.001

DO - 10.1016/j.tem.2016.01.001

M3 - Short survey

C2 - 26803729

AN - SCOPUS:84958117802

SN - 1043-2760

VL - 27

SP - 119

EP - 122

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

IS - 3

ER -

XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Abstract

Keywords

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