XBP1: A Pivotal Transcriptional Regulator of Glucose and Lipid Metabolism

Christina Piperi, Christos Adamopoulos, Athanasios G. Papavassiliou

Research output: Contribution to journalShort surveypeer-review

64 Scopus citations

Abstract

X-box binding protein 1 (XBP1) is a major, well-conserved component of the unfolded protein response (UPR) that is crucial for glucose homeostasis and lipid metabolism. Metabolic dysfunction has been associated with XBP1 transcriptional activity. Recently, compounds selectively targeting the IRE1α-XBP1 pathway have emerged as a potential approach for treatment of metabolic diseases.

Original languageEnglish
Pages (from-to)119-122
Number of pages4
JournalTrends in Endocrinology and Metabolism
Volume27
Issue number3
DOIs
StatePublished - 1 Mar 2016
Externally publishedYes

Keywords

  • Glucose
  • Lipogenesis
  • Metabolic diseases
  • Unfolded protein response
  • X-box binding protein 1

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