Work Barriers and Job Adjustments of People with Multiple Sclerosis: A Systematic Review

Bruno Kusznir Vitturi, Alborz Rahmani, Guglielmo Dini, Alfredo Montecucco, Nicoletta Debarbieri, Paolo Bandiera, Michela Ponzio, Mario Alberto Battaglia, Giampaolo Brichetto, Matilde Inglese, Benedetta Persechino, Paolo Durando

Research output: Contribution to journalArticlepeer-review


Purpose The aim was to carry out a systematic review dedicated to describing the work barriers and the job adjustments that are particularly sensitive to people with Multiple Sclerosis (PwMS). Methods Four electronic databases (PubMed/MEDLINE, Scopus, SciVerse ScienceDirect, and Web of Science) were searched for peer-reviewed original articles reporting the barriers at work and/or the job adjustments used by PwMS. MS must have been diagnosed according to accepted international criteria at the time of the study and/or confirmed by a doctor. No time limits were set for the search. Articles that were published in English, Italian, Spanish, French, and Portuguese were accepted. Each article was screened by three experienced and trained investigators. The protocol was registered in PROSPERO (CRD42022299994). Results The initial systematic search yielded 104,228 results, of which 49 articles provided sufficient information and were considered suitable for inclusion in the study. Overall, the studies included 30283 participants with MS. Thirteen (27.1%) studies reported on barriers to work, 14 (29.2%) addressed reasonable adjustments and 21 (43.7%) assessed both outcomes. Job characteristics are the most important barriers for PwMS. Other reported barriers concern the work environment, social relationships at work, negative work events and lack of information. PwMS are more vulnerable to the need for adjustments at the workplace, being the management of the workload the most commonly used one. Conclusions PwMS are exposed to a wide variety of work barriers and job adjustments. Future studies are still highly encouraged on the topic.

Original languageEnglish
JournalJournal of Occupational Rehabilitation
StateAccepted/In press - 2022
Externally publishedYes


  • Demyelinating diseases
  • Employment
  • Multiple sclerosis
  • Vocational rehabilitation
  • Work


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