TY - JOUR
T1 - Word-finding difficulty is a prevalent disease-related deficit in early multiple sclerosis
AU - Brandstadter, Rachel
AU - Fabian, Michelle
AU - Leavitt, Victoria M.
AU - Krieger, Stephen
AU - Yeshokumar, Anusha
AU - Katz Sand, Ilana
AU - Klineova, Sylvia
AU - Riley, Claire S.
AU - Lewis, Christina
AU - Pelle, Gabrielle
AU - Lublin, Fred D.
AU - Miller, Aaron E.
AU - Sumowski, James F.
N1 - Funding Information:
Three levels of evidence (patient-report, objective behavior, regional gray matter) support word-finding difficulty as a prevalent, measurable, disease-related deficit in early MS linked to left parietal cortical thinning. Multiple sclerosis language cognition parietal lobe memory demyelinating diseases Eunice Kennedy Shriver National Institute of Child Health and Human Development https://doi.org/10.13039/100009633 HD082176 edited-state corrected-proof The authors thank Angeliki Tsapanou, Korhan Buyukturkoglu, Peipei Li, Alessio Pepe, and Amgad Droby for neuroimaging analysis support. The authors also thank other collaborators on the grant, including Yaakov Stern and Christian Habeck. Finally, the authors thank patients of the RADIEMS cohort from the Corinne Goldsmith Dickinson Center for MS at Mount Sinai Hospital and the MS Center at Columbia University Medical Center. Declaration of Conflicting Interests The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Funding The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the National Institutes for Health (R01 HD082176 to J.F.S.). ORCID iDs Sylvia Klineova https://orcid.org/0000-0002-0406-0460 James F Sumowski https://orcid.org/0000-0001-6111-4907
Funding Information:
The authors thank Angeliki Tsapanou, Korhan Buyukturkoglu, Peipei Li, Alessio Pepe, and Amgad Droby for neuroimaging analysis support. The authors also thank other collaborators on the grant, including Yaakov Stern and Christian Habeck. Finally, the authors thank patients of the RADIEMS cohort from the Corinne Goldsmith Dickinson Center for MS at Mount Sinai Hospital and the MS Center at Columbia University Medical Center. The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This study was funded by the National Institutes for Health (R01 HD082176 to J.F.S.).
Publisher Copyright:
© The Author(s), 2019.
PY - 2020/11/1
Y1 - 2020/11/1
N2 - Background: Persons with multiple sclerosis (MS) commonly report word-finding difficulty clinically, yet this language deficit remains underexplored. Objective: To investigate the prevalence and nature of word-finding difficulty in persons with early MS on three levels: patient report, cognitive substrates, and neuroimaging. Methods: Two samples of early MS patients (n = 185 and n = 55; ⩽5 years diagnosed) and healthy controls (n = 50) reported frequency/severity of cognitive deficits and underwent objective assessment with tasks of rapid automatized naming (RAN), measuring lexical access speed, memory, word generation, and cognitive efficiency. High-resolution brain magnetic resonance imaging (MRI) derived measurements of regional cortical thickness, global and deep gray matter volume, and T2 lesion volume. Relationships among patient-reported word-finding difficulty, cognitive performance, and neural correlates were examined. Results: Word-finding difficulty was the most common cognitive complaint of MS patients and the only complaint reported more by patients than healthy controls. Only RAN performance discriminated MS patients with subjective word-finding deficits from those without subjective complaints and from healthy controls. Thinner left parietal cortical gray matter independently predicted impaired RAN performance, driven primarily by the left precuneus. Conclusion: Three levels of evidence (patient-report, objective behavior, regional gray matter) support word-finding difficulty as a prevalent, measurable, disease-related deficit in early MS linked to left parietal cortical thinning.
AB - Background: Persons with multiple sclerosis (MS) commonly report word-finding difficulty clinically, yet this language deficit remains underexplored. Objective: To investigate the prevalence and nature of word-finding difficulty in persons with early MS on three levels: patient report, cognitive substrates, and neuroimaging. Methods: Two samples of early MS patients (n = 185 and n = 55; ⩽5 years diagnosed) and healthy controls (n = 50) reported frequency/severity of cognitive deficits and underwent objective assessment with tasks of rapid automatized naming (RAN), measuring lexical access speed, memory, word generation, and cognitive efficiency. High-resolution brain magnetic resonance imaging (MRI) derived measurements of regional cortical thickness, global and deep gray matter volume, and T2 lesion volume. Relationships among patient-reported word-finding difficulty, cognitive performance, and neural correlates were examined. Results: Word-finding difficulty was the most common cognitive complaint of MS patients and the only complaint reported more by patients than healthy controls. Only RAN performance discriminated MS patients with subjective word-finding deficits from those without subjective complaints and from healthy controls. Thinner left parietal cortical gray matter independently predicted impaired RAN performance, driven primarily by the left precuneus. Conclusion: Three levels of evidence (patient-report, objective behavior, regional gray matter) support word-finding difficulty as a prevalent, measurable, disease-related deficit in early MS linked to left parietal cortical thinning.
KW - Multiple sclerosis
KW - cognition
KW - demyelinating diseases
KW - language
KW - memory
KW - parietal lobe
UR - http://www.scopus.com/inward/record.url?scp=85075334223&partnerID=8YFLogxK
U2 - 10.1177/1352458519881760
DO - 10.1177/1352458519881760
M3 - Article
C2 - 31741430
AN - SCOPUS:85075334223
VL - 26
SP - 1752
EP - 1764
JO - Multiple Sclerosis Journal
JF - Multiple Sclerosis Journal
SN - 1352-4585
IS - 13
ER -