Women with Symptomatic Preterm Birth Have a Distinct Cervicovaginal Metabolome

Jeny Ghartey, Laura Anglim, Julie Romero, Amy Brown, Michal A. Elovitz

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Objective The objective was to determine if women with symptoms of preterm labor who ultimately have a spontaneous preterm birth (sPTB) have a distinct cervicovaginal (CV) metabolome compared with women who deliver at term. Study Design A nested case-control study of women presenting with symptoms of preterm labor was performed. CV fluid was collected from women between 22 and 33 6/7 weeks' gestation. The CV metabolome was compared between women with sPTB (n = 20) and women who delivered at term (n = 30). Global biochemical profiles were determined using ultraperformance liquid chromatography/tandem mass spectrometry. Welch's two-sample t -test was used to identify metabolites that differed significantly. Level of significance was defined as p ≤ 0.05. Results Eighty-eight percent of women were African-American and none had a prior history of sPTB. A total of 301 metabolites were identified in CV fluid. Thirty metabolites were significantly different in women with preterm birth compared with term birth. Two metabolites (mannitol and methyl phosphate) were significantly upregulated, and the remaining 28 metabolites were significantly downregulated and consisted of medium chain-fatty acids and collagen degradation markers. Conclusion The CV metabolome is significantly altered among women who present with preterm labor symptoms and ultimately have a sPTB.

Original languageEnglish
Pages (from-to)1078-1083
Number of pages6
JournalAmerican Journal of Perinatology
Volume34
Issue number11
DOIs
StatePublished - 1 Sep 2017
Externally publishedYes

Keywords

  • cervicovaginal metabolome
  • metabolomics
  • spontaneous preterm birth
  • vaginal microbiota

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