Wnt7a-releasing hydrogel for enhancing local skeletal muscle regeneration

Woojin Han, Shannon Anderson, Mahir Mohiuddin, Andrés Garcia, Young Jang

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Statement of Purpose: Skeletal muscles efficiently regenerate upon minor injury, but their regenerative capacity is debilitated with traumatic injuries (lacerations, volumetric muscle loss) and diseases (Duchenne muscular dystrophy). Recent evidence suggests that Wnt7a induces muscle fiber hypertrophy1 and symmetric expansion of muscle stem cells2, stimulating muscle regeneration. When muscle stem cells are pre-treated with Wnt7a ex vivo, they exhibit significantly increased migration and engraftment upon transplantation.3 Although direct intramuscular injection is the simplest method to deliver Wnt7a, direct injection is not viable in many muscle trauma cases where the structural integrity is severely compromised.4 Furthermore, in Duchenne muscular dystrophy, a delivery vehicle is required to deliver Wnt7a locally to the diaphragm, a muscle critical for respiration, where direct injection is not feasible due to its thin dimensions. The objective of this work is to engineer a synthetic matrix to facilitate the delivery of Wnt7a to skeletal muscles affected by severe trauma or muscular dystrophies.

Original languageEnglish
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Pages372
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: 3 Apr 20196 Apr 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Country/TerritoryUnited States
CitySeattle
Period3/04/196/04/19

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