Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix

Héléne Salmon, Emmanuel Donnadieu

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

In principle, T cells can recognize and kill cancer cells. However, tumors have the ability to escape T cell attack. By imaging the dynamic behavior of T cells in human lung tumor explants, we have recently established the importance of the extracellular matrix in limiting access of T cells to tumor cells.

Original languageEnglish
Pages (from-to)992-994
Number of pages3
JournalOncoImmunology
Volume1
Issue number6
DOIs
StatePublished - 2012
Externally publishedYes

Keywords

  • Chemokines
  • Extracellular matrix
  • Human lung tumor
  • Migration
  • Stroma
  • T lymphocyte

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