Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using en face OCT reflectance and OCT angiography

Giselle Lynch, Jorge S.Andrade Romo, Rachel Linderman, Brian D. Krawitz, Shelley Mo, Amir Zakik, Joseph Carroll, Richard B. Rosen, Toco Y.P. Chui

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Enlargement of the foveal avascular zone (FAZ) due to progressive capillary nonperfusion is associated with visual deterioration in patients with diabetic retinopathy. The FAZ area has long been considered an important clinical marker of advancing retinopathy. However, a large body of literature shows that the FAZ area varies considerably in healthy eyes, resulting in substantial overlap between controls and diabetics, thus reducing its discriminatory value. In this study, within-subject FAZ area enlargement was obtained by the comparison of the structural FAZ area to the functional FAZ area using simultaneously-acquired, corresponding en face OCT reflectance and OCT angiography images. Our study suggests that en face OCT reflectance images provide useful anatomic baselines of structural FAZ morphology prior to the onset of disease. Measurements of within-subject FAZ area enlargement appear to be a more sensitive method for identifying the onset of diabetic retinopathy as compared to using OCT angiographic measurements of FAZ alone.

Original languageEnglish
Article number#345996
Pages (from-to)5982-5996
Number of pages15
JournalBiomedical Optics Express
Volume9
Issue number12
DOIs
StatePublished - 1 Dec 2018

Fingerprint

Dive into the research topics of 'Within-subject assessment of foveal avascular zone enlargement in different stages of diabetic retinopathy using en face OCT reflectance and OCT angiography'. Together they form a unique fingerprint.

Cite this