Withdrawal of chronic beta- adrenoceptorblockade: Effects on haemodynamics, blood lipids and haemostatic variables

P. Smith; I. Seljeflot; T. Opstad

doi:10.1007/BF02657064

Withdrawal of chronic beta- adrenoceptorblockade: Effects on haemodynamics, blood lipids and haemostatic variables

P. Smith, I. Seljeflot, T. Opstad

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effect of cessation of chronic beta-adreno-ceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal of beta-adrenoceptor-blockade, which had lasted for an average of 3 y. No effect was found on blood pressure. There was a significant increase in heart rate of 12%. Total cholesterol declined by 9%, high density lipoprotein (HDL-cholesterol) increased by 12%, and triglycerides decreased by 6%. The triglyceride dependent factors, plasminogen activator inhibitor (PAI-1) and factor VII-phospholipid complex, were not affected.

Original language	English
Pages (from-to)	81-82
Number of pages	2
Journal	European Journal of Clinical Pharmacology
Volume	39
Issue number	1
DOIs	https://doi.org/10.1007/BF02657064
State	Published - Oct 1990
Externally published	Yes

Keywords

Beta-adrenoceptorblockers
Blood lipids
Clotting factors
Drug
Haemodynamics
Withdrawal

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10.1007/BF02657064

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abstract = "The effect of cessation of chronic beta-adreno-ceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal of beta-adrenoceptor-blockade, which had lasted for an average of 3 y. No effect was found on blood pressure. There was a significant increase in heart rate of 12%. Total cholesterol declined by 9%, high density lipoprotein (HDL-cholesterol) increased by 12%, and triglycerides decreased by 6%. The triglyceride dependent factors, plasminogen activator inhibitor (PAI-1) and factor VII-phospholipid complex, were not affected.",

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AU - Opstad, T.

PY - 1990/10

Y1 - 1990/10

N2 - The effect of cessation of chronic beta-adreno-ceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal of beta-adrenoceptor-blockade, which had lasted for an average of 3 y. No effect was found on blood pressure. There was a significant increase in heart rate of 12%. Total cholesterol declined by 9%, high density lipoprotein (HDL-cholesterol) increased by 12%, and triglycerides decreased by 6%. The triglyceride dependent factors, plasminogen activator inhibitor (PAI-1) and factor VII-phospholipid complex, were not affected.

AB - The effect of cessation of chronic beta-adreno-ceptorblockade on heart rate, blood pressure, blood lipids and selected haemostatic factors have been measured in 22 patients recovering from myocardial infarction. Clinical examination and blood tests were performed before and 12 weeks after withdrawal of beta-adrenoceptor-blockade, which had lasted for an average of 3 y. No effect was found on blood pressure. There was a significant increase in heart rate of 12%. Total cholesterol declined by 9%, high density lipoprotein (HDL-cholesterol) increased by 12%, and triglycerides decreased by 6%. The triglyceride dependent factors, plasminogen activator inhibitor (PAI-1) and factor VII-phospholipid complex, were not affected.

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KW - Blood lipids

KW - Clotting factors

KW - Drug

KW - Haemodynamics

KW - Withdrawal

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Withdrawal of chronic beta- adrenoceptorblockade: Effects on haemodynamics, blood lipids and haemostatic variables

Abstract

Keywords

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