Abstract
Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.
| Original language | English |
|---|---|
| Article number | 1685841 |
| Journal | Molecular and Cellular Oncology |
| Volume | 7 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2 Jan 2020 |
Keywords
- Apoptosis
- SPARKL
- cell death
- ferroptosis
- high-throughput
- kinetics
- live-cell imaging
- necroptosis
- proliferation
- real-time analysis
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