Why not add some SPARKL to your life (and death)!?

Jesse D. Gelles, Jerry Edward Chipuk

Research output: Contribution to journalArticlepeer-review


Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.

Original languageEnglish
Article number1685841
JournalMolecular and Cellular Oncology
Issue number1
StatePublished - 2 Jan 2020


  • Apoptosis
  • cell death
  • ferroptosis
  • high-throughput
  • kinetics
  • live-cell imaging
  • necroptosis
  • proliferation
  • real-time analysis


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