Why not add some SPARKL to your life (and death)!?

Jesse D. Gelles, Jerry Edward Chipuk

Research output: Contribution to journalArticlepeer-review

Abstract

Quantifying cytostatic and cytotoxic outcomes of cells responding to perturbagens is an essential component of mechanism-based studies and pharmacological screening approaches. We recently described an easy and versatile method for single-cell and population-level analyses using real-time kinetic labeling (SPARKL). This technology enables zero-handling, non-disruptive protocols for integrating proliferation profiles with cell death mechanisms, along with advanced mathematics for robust analyses.

Original languageEnglish
Article number1685841
JournalMolecular and Cellular Oncology
Volume7
Issue number1
DOIs
StatePublished - 2 Jan 2020

Keywords

  • Apoptosis
  • SPARKL
  • cell death
  • ferroptosis
  • high-throughput
  • kinetics
  • live-cell imaging
  • necroptosis
  • proliferation
  • real-time analysis

Fingerprint

Dive into the research topics of 'Why not add some SPARKL to your life (and death)!?'. Together they form a unique fingerprint.

Cite this