Why Men's Hearts Break: Cardiovascular Effects of Sex Steroids

Brian G. Choi; Mary Ann McLaughlin

doi:10.1016/j.ecl.2007.03.011

Why Men's Hearts Break: Cardiovascular Effects of Sex Steroids

Brian G. Choi
, Mary Ann McLaughlin

Population Health Science and Policy

Research output: Contribution to journal › Review article › peer-review

48 Scopus citations

Abstract

Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.

Original language	English
Pages (from-to)	365-377
Number of pages	13
Journal	Endocrinology and Metabolism Clinics of North America
Volume	36
Issue number	2
DOIs	https://doi.org/10.1016/j.ecl.2007.03.011
State	Published - Jun 2007

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10.1016/j.ecl.2007.03.011

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title = "Why Men's Hearts Break: Cardiovascular Effects of Sex Steroids",

abstract = "Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.",

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N2 - Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.

AB - Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.

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DO - 10.1016/j.ecl.2007.03.011

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JO - Endocrinology and Metabolism Clinics of North America

JF - Endocrinology and Metabolism Clinics of North America

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ER -

Why Men's Hearts Break: Cardiovascular Effects of Sex Steroids

Abstract

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