TY - JOUR
T1 - Why Men's Hearts Break
T2 - Cardiovascular Effects of Sex Steroids
AU - Choi, Brian G.
AU - McLaughlin, Mary Ann
PY - 2007/6
Y1 - 2007/6
N2 - Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.
AB - Coronary artery disease (CAD) mortality differs in men and women, leading to the speculation that differences in sex steroids contribute to risk. Controlled clinical trials have shown that estrogen replacement is not cardioprotective in certain women, and recent cross-sectional studies associate low testosterone with a greater incidence of CAD in men. Testosterone has demonstrated effects on insulin resistance, obesity, myocardium, coagulation, inflammation, vasodilation, and endothelial function. Imbalance of sex steroids contributes to adverse cardiac effects in men.
UR - http://www.scopus.com/inward/record.url?scp=34249285167&partnerID=8YFLogxK
U2 - 10.1016/j.ecl.2007.03.011
DO - 10.1016/j.ecl.2007.03.011
M3 - Review article
C2 - 17543724
AN - SCOPUS:34249285167
SN - 0889-8529
VL - 36
SP - 365
EP - 377
JO - Endocrinology and Metabolism Clinics of North America
JF - Endocrinology and Metabolism Clinics of North America
IS - 2
ER -