Why Do Patients Undergoing Extremity Prosthetic Reconstruction for Metastatic Disease Get Readmitted?

Alexander L. Lazarides, Etienne M. Flamant, Mark C. Cullen, Harrison R. Ferlauto, Daniel E. Goltz, Niall H. Cochrane, Julia D. Visgauss, Brian E. Brigman, William C. Eward

Research output: Contribution to journalArticlepeer-review


Background: Orthopedic oncology patients are particularly susceptible to increased readmission rates and poor surgical outcomes, yet little is known about readmission rates. The goal of this study is to identify factors independently associated with 90-day readmission for patients undergoing oncologic resection and subsequent prosthetic reconstruction for metastatic disease of the hip and knee. Methods: This is a retrospective comparative cohort study of all patients treated from 2013 to 2019 at a single tertiary care referral institution who underwent endoprosthetic reconstruction by an orthopedic oncologist for metastatic disease of the extremities. The primary outcome measure was unplanned 90-day readmission. Results: We identified 112 patients undergoing 127 endoprosthetic reconstruction surgeries. Metastatic disease was most commonly from renal (26.8%), lung (23.6%), and breast (13.4%) cancer. The most common type of skeletal reconstruction performed was simple arthroplasty (54%). There were 43 readmissions overall (33.9%). When controlling for confounding factors, body mass index >40, insurance status, peripheral vascular disease, and longer hospital length of stay were independently associated with risk of readmission (P ≤ .05). Conclusion: Readmission rates for endoprosthetic reconstructions for metastatic disease are high. Although predicting readmission remains challenging, risk stratification presents a viable option for helping minimize unplanned readmissions. Level of Evidence: III.

Original languageEnglish
Pages (from-to)232-237
Number of pages6
JournalJournal of Arthroplasty
Issue number2
StatePublished - Feb 2022
Externally publishedYes


  • arthroplasty
  • extremities
  • metastatic disease
  • prosthetic reconstruction
  • readmission


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