Whole-exome sequencing for detecting inborn errors of immunity: Overview and perspectives

Isabelle Meyts, Barbara Bosch, Yuval Itan

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


The study of inborn errors of immunity is based on a comprehensive clinical description of the patient's phenotype and the elucidation of the underlying molecular mechanisms and their genetic etiology. Deciphering the pathogenesis is key to genetic counseling and the development of targeted therapy. This review shows the power of whole-exome sequencing in detecting inborn errors of immunity along five central steps taken in whole-exome sequencing analysis. In parallel, we highlight the challenges for the clinical and scientific use of the method and how these hurdles are currently being addressed. We end by ruminating on major areas in the field open to future research.

Original languageEnglish
Article number2056
StatePublished - 2017


  • Inborn errors of immunity
  • Primary immune deficiencies
  • Whole-exome sequencing


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