Whole-Body Positron Emission Tomography/Computed Tomography Imaging and Staging of Orbital Lymphoma

Richard H. Roe, Paul T. Finger, Madhavi Kurli, Lawrence B. Tena, Codrin E. Iacob

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Objectives: To report the use of whole-body positron emission tomography fused with computed tomography (PET/CT) for the diagnosis and staging of orbital lymphoma. Design: Retrospective observational case series. Participants: Four patients with biopsy-proven orbital lymphoma were evaluated by 18-fluoro-2-deoxyglucose whole-body PET/CT imaging. Methods: Positron emission tomography/CT images were studied for the presence of glucose uptake. Foci were considered suspicious based on their standardized uptake values (SUVs). Physiologic images (PET) and their anatomic counterparts (CT) were fused to allow form and function to be evaluated on the same diagnostic page. Main Outcome Measures: Positron emission tomography/CT images were assessed for foci with abnormally high SUVs that correlated with biopsy-proven lymphoma. Results: Positron emission tomography/CT detected orbital lymphoma in 3 patients (75%). It also revealed systemic lymphoma in 2 of the 4 patients. The 2 patients found to have systemic lymphoma were diagnosed to have extranodal marginal zone B-cell orbital lymphoma of the mucosa-associated lymphoid tissue (MALT) type. Similarly, the 2 with negative PET/CT results also had orbital MALT-type lymphoma. We found that PET/CT imaging helped guide further management in all 4 patients. Conclusions: Positron emission tomography/CT should be considered as a new method of diagnosing, staging, and restaging patients with orbital lymphomas.

Original languageEnglish
Pages (from-to)1854-1858
Number of pages5
JournalOphthalmology
Volume113
Issue number10
DOIs
StatePublished - Oct 2006
Externally publishedYes

Fingerprint

Dive into the research topics of 'Whole-Body Positron Emission Tomography/Computed Tomography Imaging and Staging of Orbital Lymphoma'. Together they form a unique fingerprint.

Cite this