Abstract
We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.
Original language | English |
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Pages (from-to) | 144-149 |
Number of pages | 6 |
Journal | Medical Hypotheses |
Volume | 110 |
DOIs | |
State | Published - Jan 2018 |
Externally published | Yes |
Keywords
- Cardiopulmonary bypass
- Deep Hypothermic Cardiac Arrest (DHCA)
- Endothelial nitric oxide synthase (eNOS)
- Hypoxia
- Neuroprotection
- Nitric oxide
- Pediatric surgery
- Preconditioning
- Whole Body Periodic Acceleration (pGz)