Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery

Jose A. Adams, Peter Pastuszko, Arkady Uryash, David Wilson, Jose R. Lopez Padrino, Vinay Nadkarni, Anna Pastuszko

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.

Original languageEnglish
Pages (from-to)144-149
Number of pages6
JournalMedical Hypotheses
Volume110
DOIs
StatePublished - Jan 2018
Externally publishedYes

Keywords

  • Cardiopulmonary bypass
  • Deep Hypothermic Cardiac Arrest (DHCA)
  • Endothelial nitric oxide synthase (eNOS)
  • Hypoxia
  • Neuroprotection
  • Nitric oxide
  • Pediatric surgery
  • Preconditioning
  • Whole Body Periodic Acceleration (pGz)

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