Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery

Jose A. Adams; Peter Pastuszko; Arkady Uryash; David Wilson; Jose R. Lopez Padrino; Vinay Nadkarni; Anna Pastuszko

doi:10.1016/j.mehy.2017.12.008

Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery

Jose A. Adams, Peter Pastuszko, Arkady Uryash, David Wilson, Jose R. Lopez Padrino, Vinay Nadkarni, Anna Pastuszko

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.

Original language	English
Pages (from-to)	144-149
Number of pages	6
Journal	Medical Hypotheses
Volume	110
DOIs	https://doi.org/10.1016/j.mehy.2017.12.008
State	Published - Jan 2018
Externally published	Yes

Keywords

Cardiopulmonary bypass
Deep Hypothermic Cardiac Arrest (DHCA)
Endothelial nitric oxide synthase (eNOS)
Hypoxia
Neuroprotection
Nitric oxide
Pediatric surgery
Preconditioning
Whole Body Periodic Acceleration (pGz)

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10.1016/j.mehy.2017.12.008

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title = "Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery",

abstract = "We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.",

keywords = "Cardiopulmonary bypass, Deep Hypothermic Cardiac Arrest (DHCA), Endothelial nitric oxide synthase (eNOS), Hypoxia, Neuroprotection, Nitric oxide, Pediatric surgery, Preconditioning, Whole Body Periodic Acceleration (pGz)",

author = "Adams, {Jose A.} and Peter Pastuszko and Arkady Uryash and David Wilson and {Lopez Padrino}, {Jose R.} and Vinay Nadkarni and Anna Pastuszko",

note = "Funding Information: This work was partially funded through a grant from the Florida Heart Research Institute Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

year = "2018",

month = jan,

doi = "10.1016/j.mehy.2017.12.008",

language = "English",

volume = "110",

pages = "144--149",

journal = "Medical Hypotheses",

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AU - Adams, Jose A.

AU - Pastuszko, Peter

AU - Uryash, Arkady

AU - Wilson, David

AU - Lopez Padrino, Jose R.

AU - Nadkarni, Vinay

AU - Pastuszko, Anna

PY - 2018/1

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AB - We hypothesized that pGz has cardio and neuroprotective effects due to upregulation of pathways which include eNOS, anti-apoptotic, and anti-inflammatory pathways. We analyze protein expression of these pathways in the brain of neonatal piglets, as well as report on the myocardial function after Deep Hypothermic Circulatory Arrest (DHCA) and pGz preconditioning. Animal data affirms both a cardio and neuroprotective role for pGz. These findings suggest that pGz can be a simple, non-invasive cardio and neuroprotective strategy preconditioning strategy in children requiring surgical intervention.

KW - Cardiopulmonary bypass

KW - Deep Hypothermic Cardiac Arrest (DHCA)

KW - Endothelial nitric oxide synthase (eNOS)

KW - Hypoxia

KW - Neuroprotection

KW - Nitric oxide

KW - Pediatric surgery

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KW - Whole Body Periodic Acceleration (pGz)

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Whole Body Periodic Acceleration (pGz) as a non-invasive preconditioning strategy for pediatric cardiac surgery

Abstract

Keywords

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