Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization

V. Y. Panin; H. Bal; M. Defrise; M. E. Casey; N. A. Karakatsanis; A. Rahmim

doi:10.1109/NSSMIC.2015.7582244

Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization

V. Y. Panin, H. Bal, M. Defrise, M. E. Casey, N. A. Karakatsanis, A. Rahmim

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

7 Scopus citations

Abstract

Whole body dynamic PET imaging has the potential to enhance detectability and quantification when assessing disease stage or progress. The same body region is repeatedly scanned within relatively short acquisition frames and with delays between time samples. Repeated scanning is sensitive to patient motion, which may cause mismatches between attenuation and activity maps and thus erroneous correction factors. Moreover, since count rates change with time, standard software correction factors can be time dependent. The generation of parametric images requires proper physiological modeling and has been shown to benefit from so-called direct 4D reconstruction methods. In this work we extend the MLACF/MLAA algorithms for application to dynamic direct reconstruction. Handling time-dependent normalization requires a redesign of the existing algorithm as well. The reconstruction methodology was verified on Siemens mCT scanner patient data using the standard Patlak model. Different number of frames and scan initiation time points were investigated. Initial results showed that direct 4D reconstruction outperformed the indirect approach. Available CT attenuation information can be corrected based on emission data.

Original language	English
Title of host publication	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)	9781467398626
DOIs	https://doi.org/10.1109/NSSMIC.2015.7582244
State	Published - 3 Oct 2016
Event	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 - San Diego, United States Duration: 31 Oct 2015 → 7 Nov 2015

Publication series

Name	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015

Conference

Conference	2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015
Country/Territory	United States
City	San Diego
Period	31/10/15 → 7/11/15

Access to Document

10.1109/NSSMIC.2015.7582244

Cite this

Panin, V. Y., Bal, H., Defrise, M., Casey, M. E., Karakatsanis, N. A., & Rahmim, A. (2016). Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015 Article 7582244 (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2015.7582244

Panin, V. Y. ; Bal, H. ; Defrise, M. et al. / Whole body parametric imaging on clinical scanner : Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization. 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015).

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title = "Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization",

abstract = "Whole body dynamic PET imaging has the potential to enhance detectability and quantification when assessing disease stage or progress. The same body region is repeatedly scanned within relatively short acquisition frames and with delays between time samples. Repeated scanning is sensitive to patient motion, which may cause mismatches between attenuation and activity maps and thus erroneous correction factors. Moreover, since count rates change with time, standard software correction factors can be time dependent. The generation of parametric images requires proper physiological modeling and has been shown to benefit from so-called direct 4D reconstruction methods. In this work we extend the MLACF/MLAA algorithms for application to dynamic direct reconstruction. Handling time-dependent normalization requires a redesign of the existing algorithm as well. The reconstruction methodology was verified on Siemens mCT scanner patient data using the standard Patlak model. Different number of frames and scan initiation time points were investigated. Initial results showed that direct 4D reconstruction outperformed the indirect approach. Available CT attenuation information can be corrected based on emission data.",

author = "Panin, \{V. Y.\} and H. Bal and M. Defrise and Casey, \{M. E.\} and Karakatsanis, \{N. A.\} and A. Rahmim",

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doi = "10.1109/NSSMIC.2015.7582244",

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Panin, VY, Bal, H, Defrise, M, Casey, ME, Karakatsanis, NA & Rahmim, A 2016, Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization. in 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015., 7582244, 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, Institute of Electrical and Electronics Engineers Inc., 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015, San Diego, United States, 31/10/15. https://doi.org/10.1109/NSSMIC.2015.7582244

Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization. / Panin, V. Y.; Bal, H.; Defrise, M. et al.
2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc., 2016. 7582244 (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Panin VY, Bal H, Defrise M, Casey ME, Karakatsanis NA, Rahmim A. Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization. In 2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015. Institute of Electrical and Electronics Engineers Inc. 2016. 7582244. (2015 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2015). doi: 10.1109/NSSMIC.2015.7582244

Whole body parametric imaging on clinical scanner: Direct 4D reconstruction with simultaneous attenuation estimation and time-dependent normalization

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