TY - JOUR
T1 - White-matter damage in clade C HIV-positive subjects
T2 - A diffusion tensor imaging study
AU - Hoare, Jacqueline
AU - Fouche, Jean Paul
AU - Spottiswoode, Bruce
AU - Sorsdahl, Katherine
AU - Combrinck, Marc
AU - Stein, Dan J.
AU - Paul, Robert H.
AU - Joska, John A.
PY - 2011
Y1 - 2011
N2 - The relationship between cognitive impairment and white-matter integrity in human immunodeficiency virus (HIV) remains poorly understood, particularly in clade C. The authors utilized diffusion tensor imaging (DTI) and a comprehensive neuropsychological evaluation to investigate the relationship between cognitive impairment and white-matter integrity in HIV-positive subjects with clade C HIV. Forty-four HIV-infected individuals and 10 seronegative subjects were compared, using a whole-brain, voxel-based approach to define fractional anisot-ropy (FA) and mean diffusion (MD). Compared with healthy-control subjects, the HIV-infected group exhibited decreased FA in the corpus callo-sum, superior longitudinal fasciculus, and cingu-lum and sagittal stratum. This study provides evidence that white-matter integrity is compromised in individuals infected with clade C HIV.
AB - The relationship between cognitive impairment and white-matter integrity in human immunodeficiency virus (HIV) remains poorly understood, particularly in clade C. The authors utilized diffusion tensor imaging (DTI) and a comprehensive neuropsychological evaluation to investigate the relationship between cognitive impairment and white-matter integrity in HIV-positive subjects with clade C HIV. Forty-four HIV-infected individuals and 10 seronegative subjects were compared, using a whole-brain, voxel-based approach to define fractional anisot-ropy (FA) and mean diffusion (MD). Compared with healthy-control subjects, the HIV-infected group exhibited decreased FA in the corpus callo-sum, superior longitudinal fasciculus, and cingu-lum and sagittal stratum. This study provides evidence that white-matter integrity is compromised in individuals infected with clade C HIV.
UR - http://www.scopus.com/inward/record.url?scp=80055002805&partnerID=8YFLogxK
U2 - 10.1176/jnp.23.3.jnp308
DO - 10.1176/jnp.23.3.jnp308
M3 - Article
AN - SCOPUS:80055002805
SN - 0895-0172
VL - 23
SP - 308
EP - 315
JO - Journal of Neuropsychiatry and Clinical Neurosciences
JF - Journal of Neuropsychiatry and Clinical Neurosciences
IS - 3
ER -