When mutants gain new powers: News from the mutant p53 field

Ran Brosh, Varda Rotter

Research output: Contribution to journalReview articlepeer-review

841 Scopus citations

Abstract

Ample data indicate that mutant p53 proteins not only lose their tumour suppressive functions, but also gain new abilities that promote tumorigenesis. Moreover, recent studies have modified our view of mutant p53 proteins, portraying them not as inert mutants, but rather as regulated proteins that influence the cancer cell transcriptome and phenotype. This influence is clinically manifested as association of TP53 mutations with poor prognosis and drug resistance in a growing array of malignancies. Here, we review recent studies on mutant p53 regulation, gain-of-function mechanisms, transcriptional effects and prognostic association, with a focus on the clinical implications of these findings.

Original languageEnglish
Pages (from-to)701-713
Number of pages13
JournalNature Reviews Cancer
Volume9
Issue number10
DOIs
StatePublished - Oct 2009
Externally publishedYes

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