TY - JOUR
T1 - When an Intruder Comes Home
T2 - GM and GE Strategies to Combat Virus Infection in Plants
AU - Rahman, Adeeb
AU - Sanan-Mishra, Neeti
N1 - Publisher Copyright:
© 2024 by the authors.
PY - 2024/2
Y1 - 2024/2
N2 - Viruses are silent enemies that intrude and take control of the plant cell’s machinery for their own multiplication. Infection by viruses and the resulting damage is still a major challenge in the agriculture sector. Plants have the capability to fight back, but the ability of viruses to mutate at a fast rate helps them to evade the host’s response. Therefore, classical approaches for introgressing resistance genes by breeding have obtained limited success in counteracting the virus menace. Genetic modification (GM)-based strategies have been successful in engineering artificial resistance in plants. Several different approaches based on pathogen-derived resistance, antisense constructs, hairpin RNAs, double-stranded RNA, etc., have been used to enhance plants’ resistance to viruses. Recently, genome editing (GE) strategies mainly involving the CRISPR/Cas-mediated modifications are being used for virus control. In this review, we discuss the developments and advancements in GM- and GE-based methods for tackling viral infection in plants.
AB - Viruses are silent enemies that intrude and take control of the plant cell’s machinery for their own multiplication. Infection by viruses and the resulting damage is still a major challenge in the agriculture sector. Plants have the capability to fight back, but the ability of viruses to mutate at a fast rate helps them to evade the host’s response. Therefore, classical approaches for introgressing resistance genes by breeding have obtained limited success in counteracting the virus menace. Genetic modification (GM)-based strategies have been successful in engineering artificial resistance in plants. Several different approaches based on pathogen-derived resistance, antisense constructs, hairpin RNAs, double-stranded RNA, etc., have been used to enhance plants’ resistance to viruses. Recently, genome editing (GE) strategies mainly involving the CRISPR/Cas-mediated modifications are being used for virus control. In this review, we discuss the developments and advancements in GM- and GE-based methods for tackling viral infection in plants.
KW - RNA silencing
KW - artificial miRNA
KW - epigenetic editing
KW - multiplexing CRISPR/Cas editing
KW - pathogen-derived resistance
KW - prime editing
KW - tasiRNA
UR - http://www.scopus.com/inward/record.url?scp=85187267234&partnerID=8YFLogxK
U2 - 10.3390/agriculture14020282
DO - 10.3390/agriculture14020282
M3 - Review article
AN - SCOPUS:85187267234
SN - 2077-0472
VL - 14
JO - Agriculture (Switzerland)
JF - Agriculture (Switzerland)
IS - 2
M1 - 282
ER -