What are the major arguments in favour of the genetic susceptibility for inflammatory bowel disease?

Cyrus P. Tamboli, Antoine Cortot, Jean Frédéric Colombel

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Epidemiological data, notably concordance rates in twin pairs and familial aggregation, have provided strong evidence for the importance of the genetic contribution in inflammatory bowel diseases. Genome wide scanning has been remarkably successful in identifying a number of susceptibility loci. The identification of the IBD1 gene on chromosome 16 as NOD2/CARD15 definitely establishes that a significant proportion of Crohn's disease has an underlying genetic cause. In addition, our knowledge of the clinical impact of other genes in modelling disease phenotypes has increased in parallel. These results have led to great optimism that important clinical applications will result from genetic research in the near future.

Original languageEnglish
Pages (from-to)587-592
Number of pages6
JournalEuropean Journal of Gastroenterology and Hepatology
Volume15
Issue number6
DOIs
StatePublished - 1 Jun 2003
Externally publishedYes

Keywords

  • Crohn's disease
  • Genetics
  • Inflammatory bowel disease
  • Ulcerative colitis

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