What are RBC-transfusion-dependence and -independence?

R. P. Gale; G. Barosi; T. Barbui; F. Cervantes; K. Dohner; B. Dupriez; V. Gupta; C. Harrison; R. Hoffman; J. J. Kiladjian; R. Mesa; M. F. Mc Mullin; F. Passamonti; V. Ribrag; G. Roboz; G. Saglio; A. Vannucchi; S. Verstovsek

doi:10.1016/j.leukres.2010.07.015

What are RBC-transfusion-dependence and -independence?

R. P. Gale, G. Barosi, T. Barbui, F. Cervantes, K. Dohner, B. Dupriez, V. Gupta, C. Harrison, R. Hoffman, J. J. Kiladjian, R. Mesa, M. F. Mc Mullin, F. Passamonti, V. Ribrag, G. Roboz, G. Saglio, A. Vannucchi, S. Verstovsek

Research output: Contribution to journal › Letter › peer-review

82 Scopus citations

Abstract

The term RBC-transfusion-dependence is widely-used by hematologists to describe a condition of severe anemia typically arising when erythropoiesis is reduced such that a person continuously requires ≥1 RBC-transfusions over a specified interval. Defining a person as RBC-transfusion-dependent has important implications in diverse hematological disorders especially because it strongly-correlated with decreased survival. Conversely, becoming RBC-transfusion-independent or receiving fewer RBC-transfusions over a specified interval is defined as improvement or response in many disease- and/or therapy-setting. Whether this correlates with improved survival is controversial. We used a structured expert-panel consensus panel process to define RBC-transfusion-dependence and -independence or improvement. We suggest these definitions may prove useful to persons studying or treating these diseases.

Original language	English
Pages (from-to)	8-11
Number of pages	4
Journal	Leukemia Research
Volume	35
Issue number	1
DOIs	https://doi.org/10.1016/j.leukres.2010.07.015
State	Published - Jan 2011

Keywords

Anemia
Anemia therapy
Aplastic anemia
Myelodysplastic syndrome
Myeloproliferative neoplasm
Paroxysmal nocturnal hemoglobinuria
RBC-transfusions

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10.1016/j.leukres.2010.07.015

Cite this

Gale, R. P., Barosi, G., Barbui, T., Cervantes, F., Dohner, K., Dupriez, B., Gupta, V., Harrison, C., Hoffman, R., Kiladjian, J. J., Mesa, R., Mc Mullin, M. F., Passamonti, F., Ribrag, V., Roboz, G., Saglio, G., Vannucchi, A., & Verstovsek, S. (2011). What are RBC-transfusion-dependence and -independence? Leukemia Research, 35(1), 8-11. https://doi.org/10.1016/j.leukres.2010.07.015

@article{5064cbf658cb40ceb704fd8becc4799b,

title = "What are RBC-transfusion-dependence and -independence?",

abstract = "The term RBC-transfusion-dependence is widely-used by hematologists to describe a condition of severe anemia typically arising when erythropoiesis is reduced such that a person continuously requires ≥1 RBC-transfusions over a specified interval. Defining a person as RBC-transfusion-dependent has important implications in diverse hematological disorders especially because it strongly-correlated with decreased survival. Conversely, becoming RBC-transfusion-independent or receiving fewer RBC-transfusions over a specified interval is defined as improvement or response in many disease- and/or therapy-setting. Whether this correlates with improved survival is controversial. We used a structured expert-panel consensus panel process to define RBC-transfusion-dependence and -independence or improvement. We suggest these definitions may prove useful to persons studying or treating these diseases.",

keywords = "Anemia, Anemia therapy, Aplastic anemia, Myelodysplastic syndrome, Myeloproliferative neoplasm, Paroxysmal nocturnal hemoglobinuria, RBC-transfusions",

author = "Gale, {R. P.} and G. Barosi and T. Barbui and F. Cervantes and K. Dohner and B. Dupriez and V. Gupta and C. Harrison and R. Hoffman and Kiladjian, {J. J.} and R. Mesa and {Mc Mullin}, {M. F.} and F. Passamonti and V. Ribrag and G. Roboz and G. Saglio and A. Vannucchi and S. Verstovsek",

year = "2011",

month = jan,

doi = "10.1016/j.leukres.2010.07.015",

language = "English",

volume = "35",

pages = "8--11",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Elsevier Ltd.",