Weight gain in gestational diabetes: The effect of treatment modality

Lois E. Brustman, Oded Langer, Brianne Bimson, Sophia Scarpelli, Manal El Daouk

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Objective: To evaluate treatment effectiveness (diet alone, insulin or glyburide) on maternal weight gain in gestational diabetes (GDM).Methods: GDM patients were treated with diet alone, insulin or glyburide. Weight gain was stratified into: prior to GDM diagnosis, from diagnosis to delivery and total pregnancy weight gain. Good glycemic control was defined as mean blood glucose ≤105 mg/dl and obesity as Body Mass Index (BMI) ≥ 30 kg/m2, overweight BMI 25-29 kg/m2 and normal < 25 kg/m2.Results: Total weight gain was similar in all the treatment groups. Two-Thirds of weight gain occurred prior to diagnosis (diet 85%, insulin 67% and glyburide 78%). Post-diagnosis, patients on diet alone gained less weight than those on insulin or glyburide (p < 0.001); insulin-Treated patients showed greater weight gain than glyburide-Treated patients (p < 0.001). Patients on diet with good glycemic control showed less weight gain after diagnosis than patients on insulin or glyburide (2.8 ± 13, 6.6 ± 10, 5.2 ± 7.9 lbs, respectively, p < 0.02). Poorly-controlled patients, regardless of treatment, had similar patterns of weight gain throughout pregnancy.Conclusion: Patterns of maternal weight gain in GDM pregnancies are associated with treatment modality and level of glycemic control.

Original languageEnglish
Pages (from-to)1025-1029
Number of pages5
JournalJournal of Maternal-Fetal and Neonatal Medicine
Issue number7
StatePublished - 2 Apr 2016
Externally publishedYes


  • GDM
  • glyburide
  • glycemic control
  • insulin
  • weight gain in pregnancy


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