Water permeability of the toad corneal epithelium: The effects of pH and amphotericin B

Mario Parisi, Oscar Candia, Lawrence Alvarez

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The water diffusional permeability of the toad cornea was evaluated from THO measurements, while taking into account the influence of unstirred layers. The corneal epithelium is a restrictive barrier for water diffusion and its permeability can be increased by amphotericin B or Triton X-100. In animals maintained in tap water, the epithelial water permeability was reversibly inhibited by the acidification of the solution bathing the tear side of the cornea. When toads were adapted to a saline environment, a reduction of epithelial water permeability with a loss of sensitivity to changes in the tear side medium pH was observed.

Original languageEnglish
Pages (from-to)131-136
Number of pages6
JournalPflugers Archiv European Journal of Physiology
Volume383
Issue number2
DOIs
StatePublished - Jan 1980

Keywords

  • Amphotericin B
  • Medium pH
  • Toad cornea
  • Water permeability

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