Vulnerable Plaque Imaging

Takehiro Nakahara, H. William Strauss, Jagat Narula, Mahahiro Jinzaki

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Atherosclerotic plaques progress as a result of inflammation. Both invasive and noninvasive imaging techniques have been developed to identify and characterize plaque as vulnerable (more likely to rupture and cause a clinical event). Imaging techniques to identify vulnerable include identifying vessels with focal subendothelial collections of I) inflammatory cells; II) lipid/ fatty acid; III) local regions of hypoxia; IV) local expression of angiogenesis factors; V) local expression of protease; VI) intravascular foci of thrombus; hemorrhage (most often seen in the aftermath of a clinical event); VII) apoptosis and VIII) microcalcification. This review provides an overview of atherosclerotic plaque progression and tracers which can visualize specific molecules associated with vulnerability.

Original languageEnglish
Pages (from-to)230-240
Number of pages11
JournalSeminars in Nuclear Medicine
Issue number2
StatePublished - Mar 2023


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