TY - JOUR
T1 - von Willebrand's disease
T2 - A comparative studyof diagnostic tests
AU - Abildgaard, Charles F.
AU - Simone, Joseph V.
AU - Honig, George R.
AU - Forman, Edwin N.
AU - Johnson, Christine A.
AU - Seeler, Ruth A.
N1 - Funding Information:
From the Department of Pediatrics, University o/Illinois College o/ Medicine. Supported by graduate training Grant No. T1-AM-5344 #ore the National Institute o/ Arthritis and Metabolic Diseases, Grant No. RG HE-07418 \[rom the National Heart Institute, and Grant No. RG HD-00568 #ore the National Institute of Child Health and Human Development, National Institutes of Health; United States Public Health Service.
PY - 1968/9
Y1 - 1968/9
N2 - The comparative diagnostic value of the Duke, Ivy, and modified Ivy bleeding times, factor VIII assay, and in vivo and in vitro platelet adhesiveness was determined in 28 patients with von Willebrand's disease. The combination of Duke and modified Ivy bleeding times plus factor VIII assay was adequate to detect an abnormality in all patients studied. Variability of the bleeding times and factor VIII level in some patients may make repeated testing necessary. Presently available tests of platelet adhesiveness may be abnormal in patients with von Willebrand's disease, but are not necessary for the diagnosis and may give false positive results.
AB - The comparative diagnostic value of the Duke, Ivy, and modified Ivy bleeding times, factor VIII assay, and in vivo and in vitro platelet adhesiveness was determined in 28 patients with von Willebrand's disease. The combination of Duke and modified Ivy bleeding times plus factor VIII assay was adequate to detect an abnormality in all patients studied. Variability of the bleeding times and factor VIII level in some patients may make repeated testing necessary. Presently available tests of platelet adhesiveness may be abnormal in patients with von Willebrand's disease, but are not necessary for the diagnosis and may give false positive results.
UR - https://www.scopus.com/pages/publications/0014325774
U2 - 10.1016/S0022-3476(68)80112-X
DO - 10.1016/S0022-3476(68)80112-X
M3 - Article
C2 - 5302133
AN - SCOPUS:0014325774
SN - 0022-3476
VL - 73
SP - 355
EP - 363
JO - Journal of Pediatrics
JF - Journal of Pediatrics
IS - 3
ER -