TY - JOUR
T1 - Volumetric and topographic differences in hippocampal subdivisions in borderline personality and bipolar disorders
AU - Rossi, Roberta
AU - Lanfredi, Mariangela
AU - Pievani, Michela
AU - Boccardi, Marina
AU - Beneduce, Rossella
AU - Rillosi, Luciana
AU - Giannakopoulos, Panteleimon
AU - Thompson, Paul M.
AU - Rossi, Giuseppe
AU - Frisoni, Giovanni B.
N1 - Funding Information:
This work was financially supported by the Italian Ministry of Health , and AFaR (Associazione Fatebenefratelli per la Ricerca) — Rome, Italy.
PY - 2012/8
Y1 - 2012/8
N2 - Hippocampal abnormalities may be implicated in the pathophysiology of mental disorders with affective symptoms such as borderline personality disorder (BPD) and bipolar disorder (BD). We aimed to investigate hippocampal morphology in BPD and BD patients, compared to 1:1 age- and sex-matched healthy controls (HC) using a three-dimensional mapping method. Manual tracing of the hippocampi on magnetic resonance imaging (MRI) images was performed on 26 patients with BPD (age: 38 ± 11; sex (f): 16 (61%)) and 15 with BD (age: 44 ± 9; sex (f): 5 (33%)) and their age- and sex-matched HC (for BPD: n= 26; age: 38 ± 11; sex (f): 16 (61%); for BD: n= 15; age: 44 ± 9; sex (f): 5 (33%)). Compared to their reference groups, BPD patients showed smaller hippocampal volume bilaterally. The BD group showed significantly smaller right hippocampal volumes. In the surface maps, alterations were localized to different hippocampal sectors for the two groups: the CA1 regions and subiculum, bilaterally, in BPD, and the right dentate gyrus in the BD group. These differences persisted after controlling for alcohol and substance abuse. BPD and BD groups may exhibit distinct patterns of volumetric MRI changes in hippocampal subdivisions that might be related to the clinical phenomenology of each disorder.
AB - Hippocampal abnormalities may be implicated in the pathophysiology of mental disorders with affective symptoms such as borderline personality disorder (BPD) and bipolar disorder (BD). We aimed to investigate hippocampal morphology in BPD and BD patients, compared to 1:1 age- and sex-matched healthy controls (HC) using a three-dimensional mapping method. Manual tracing of the hippocampi on magnetic resonance imaging (MRI) images was performed on 26 patients with BPD (age: 38 ± 11; sex (f): 16 (61%)) and 15 with BD (age: 44 ± 9; sex (f): 5 (33%)) and their age- and sex-matched HC (for BPD: n= 26; age: 38 ± 11; sex (f): 16 (61%); for BD: n= 15; age: 44 ± 9; sex (f): 5 (33%)). Compared to their reference groups, BPD patients showed smaller hippocampal volume bilaterally. The BD group showed significantly smaller right hippocampal volumes. In the surface maps, alterations were localized to different hippocampal sectors for the two groups: the CA1 regions and subiculum, bilaterally, in BPD, and the right dentate gyrus in the BD group. These differences persisted after controlling for alcohol and substance abuse. BPD and BD groups may exhibit distinct patterns of volumetric MRI changes in hippocampal subdivisions that might be related to the clinical phenomenology of each disorder.
KW - Bipolar disorder
KW - Borderline personality disorder
KW - Hippocampal abnormalities
KW - Hippocampal morphology
UR - http://www.scopus.com/inward/record.url?scp=84867141222&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2011.12.004
DO - 10.1016/j.pscychresns.2011.12.004
M3 - Article
C2 - 22944368
AN - SCOPUS:84867141222
SN - 0925-4927
VL - 203
SP - 132
EP - 138
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
IS - 2-3
ER -