Vitamin e intake is not associated with glioma risk: Evidence from a meta-analysis

Shiyong Qin, Minghai Wang, Tao Zhang, Shuguang Zhang

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

Background: Epidemiological studies evaluating the association between vitamin E intake and glioma risk have produced inconsistent results. Thus, we conducted a meta-analysis to summarize the evidence from epidemiological studies of vitamin E intake with the risk of glioma. Methods: Pertinent studies were identified by a search in pubmed and web of knowledge up to August 2014. The random-effect model was used to combine the results. Publication bias was estimated using the Egger's regression asymmetry test. Results: Twelve studies including 3180 glioma cases about vitamin E intake with the risk of glioma were included in this meta-analysis. The combined relative risk (RR) of glioma associated with vitamin E intake was 0.88 (95% CI = 0.69-1.12). The association was significant neither in the case-control studies nor in the cohort studies. No publication biases were found. Conclusions: Our analysis indicated that vitamin E intake is not associated with the risk of glioma.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalNeuroepidemiology
Volume43
Issue number3-4
DOIs
StatePublished - 16 Apr 2014
Externally publishedYes

Keywords

  • Glioma
  • Meta-analysis
  • Vitamin E

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