Vitamin D regulation of adipogenesis and adipose tissue functions

Hataikarn Nimitphong, Eunmi Park, Mi Jeong Lee

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to be altered in obesity. Sequestration of vitamin D in large amount of adipose tissues and low vitamin D metabolism may contribute to the vitamin D inadequacy in obesity. Vitamin D receptor is expressed in adipose tissues and vitamin D regulates multiple aspects of adipose biology including adipogenesis as well as metabolic and endocrine function of adipose tissues that can contribute to the high risk of metabolic diseases in vitamin D insufficiency. We will review current understanding of vitamin D regulation of adipose biology focusing on vitamin D modulation of adiposity and adipose tissue functions as well as the molecular mechanisms through which vitamin D regulates adipose biology. The effects of supplementation or maintenance of vitamin D on obesity and metabolic diseases are also discussed.

Original languageEnglish
Pages (from-to)553-567
Number of pages15
JournalNutrition Research and Practice
Volume14
Issue number6
DOIs
StatePublished - Dec 2020
Externally publishedYes

Keywords

  • Adipogenesis
  • Adipose function
  • Cholecalciferol
  • Metabolic diseases
  • Obesity

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