TY - GEN
T1 - Vita-PAMPs
T2 - Signatures of microbial viability
AU - Mourao-Sa, Diego
AU - Roy, Soumit
AU - Blander, J. Magarian
PY - 2013
Y1 - 2013
N2 - Can the innate immune system detect and respond to microbial viability? Using bacteria as a model, we found that indeed the very essence of microbial infectivity, viability itself, can be detected, and notably, in the absence of the activity of virulence factors. The microbial molecule that serves as the signature of viability is bacterial messenger RNA (mRNA), common to all bacteria, and without which bacteria cannot survive. Prokaryotic mRNAs also differ from eukaryotic mRNAs in several ways, and as such, these features all fulfill the criteria, and more, for a pathogen-associated molecular pattern (PAMP) as originally proposed by Charles Janeway. Because these mRNAs are lost from dead bacteria, they belong to a special class of PAMPs, which we call vita-PAMPs. Here we discuss the possible receptors and pathways involved in the detection of bacterial mRNAs, and thus microbial viability. We also consider examples of vita-PAMPs other than bacterial mRNA.
AB - Can the innate immune system detect and respond to microbial viability? Using bacteria as a model, we found that indeed the very essence of microbial infectivity, viability itself, can be detected, and notably, in the absence of the activity of virulence factors. The microbial molecule that serves as the signature of viability is bacterial messenger RNA (mRNA), common to all bacteria, and without which bacteria cannot survive. Prokaryotic mRNAs also differ from eukaryotic mRNAs in several ways, and as such, these features all fulfill the criteria, and more, for a pathogen-associated molecular pattern (PAMP) as originally proposed by Charles Janeway. Because these mRNAs are lost from dead bacteria, they belong to a special class of PAMPs, which we call vita-PAMPs. Here we discuss the possible receptors and pathways involved in the detection of bacterial mRNAs, and thus microbial viability. We also consider examples of vita-PAMPs other than bacterial mRNA.
KW - Bacterial messenger RNA
KW - Inflammasome
KW - Pattern recognition
KW - Toll-like receptor
KW - Type I interferon
KW - Vaccine
KW - Virulence factors
UR - https://www.scopus.com/pages/publications/84934437018
U2 - 10.1007/978-1-4614-6217-0_1
DO - 10.1007/978-1-4614-6217-0_1
M3 - Conference contribution
C2 - 23456832
AN - SCOPUS:84934437018
SN - 9781461462163
T3 - Advances in Experimental Medicine and Biology
SP - 1
EP - 8
BT - Crossroads Between Innate and Adaptive Immunity IV
PB - Springer New York LLC
ER -