Visuo-cognitive dysfunctions in Parkinson's disease

Andrea Antal, Fabio Bandini, Szabolcs Kéri, Iván Bodis-Wollner

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

Loss of will, decreased activity, and poverty of behavior are among the common symptoms observed in Parkinson's disease (PD). In line with these clinical observations, PD patients display prominent deficit in neuropsychological tests, requiring self-generated and effort-demanding operations. However, recent evidence suggests that this impairment is not generalized: visuo-spatial working memory and attentional setshifting seem to be selectively impaired in the early stages of the disease. Electrophysiological studies also demonstrate the dysfunction of higher-level visual information processing. In this article, we discuss some current results to show the connection between clinical symptoms and neuropsychological deficits. We also consider dysfunction in underlying neural mechanisms, with particular emphasis on the dysregulation of fronto-striatal circuits. However, it is conceivable that visuo-cognitive impairment in PD reflects dysfunction of neural assemblies, involving basal ganglia, dorsal visual stream, and frontal-prefrontal circuits.

Original languageEnglish
Pages (from-to)147-152
Number of pages6
JournalClinical Neuroscience
Volume5
Issue number2
StatePublished - 1998
Externally publishedYes

Keywords

  • Electrophysiology
  • Fronto-striatal
  • Parkinson's disease
  • Spatial and object vision
  • Visual P300
  • Visuo-cognitive
  • Working memory

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