Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the homes of asthmatic and non-asthmatic children in New York City

Rachael E. Rush, Karen C. Dannemiller, Samuel J. Cochran, Sarah R. Haines, Luis Acosta, Adnan Divjan, Andrew G. Rundle, Rachel L. Miller, Matthew S. Perzanowski, Tara L. Croston, Brett J. Green

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background: Indoor environments contain a broad diversity of non-pathogenic Basidiomycota yeasts, but their role in exacerbating adverse health effects has remained unclear. Objective: To understand the role of Vishniacozyma victoriae exposure and its impact on human health. Methods: A qPCR assay was developed to detect and quantify an abundant indoor yeast species, Vishniacozyma victoriae (syn. Cryptococcus victoriae), from homes participating in the New York City Neighborhood Asthma and Allergy Study (NAAS). We evaluated the associations between V. victoriae, housing characteristics, and asthma relevant health endpoints. Results: V. victoriae was quantified in 236 of the 256 bedroom floor dust samples ranging from less than 300–45,918 cell equivalents/mg of dust. Higher concentrations of V. victoriae were significantly associated with carpeted bedroom floors (P = 0.044), mean specific humidity (P = 0.004), winter (P < 0.0001) and spring (P = 0.001) seasons, and the presence of dog (P = 0.010) and dog allergen Can f 1 (P = 0.027). V. victoriae concentrations were lower in homes of children with asthma vs. without asthma (P = 0.027), an association observed only among the non-seroatopic children.

Original languageEnglish
Pages (from-to)48-59
Number of pages12
JournalJournal of Exposure Science and Environmental Epidemiology
Volume32
Issue number1
DOIs
StatePublished - Jan 2022

Keywords

  • Allergy
  • Asthma
  • Cryptococcus
  • ITS
  • Yeast
  • qPCR

Fingerprint

Dive into the research topics of 'Vishniacozyma victoriae (syn. Cryptococcus victoriae) in the homes of asthmatic and non-asthmatic children in New York City'. Together they form a unique fingerprint.

Cite this