Virus subversion of immunity: A structural perspective

Benjamin E. Gewurz; Rachelle Gaudet; Domenico Tortorella; Evelyn W. Wang; Hidde L. Ploegh

doi:10.1016/S0952-7915(00)00239-9

Virus subversion of immunity: A structural perspective

Benjamin E. Gewurz, Rachelle Gaudet, Domenico Tortorella, Evelyn W. Wang, Hidde L. Ploegh

Research output: Contribution to journal › Review article › peer-review

50 Scopus citations

Abstract

Over the past year, we have witnessed the discovery of further virus immuno-evasins - proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.

Original language	English
Pages (from-to)	442-450
Number of pages	9
Journal	Current Opinion in Immunology
Volume	13
Issue number	4
DOIs	https://doi.org/10.1016/S0952-7915(00)00239-9
State	Published - 1 Aug 2001
Externally published	Yes

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title = "Virus subversion of immunity: A structural perspective",

abstract = "Over the past year, we have witnessed the discovery of further virus immuno-evasins - proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.",

author = "Gewurz, {Benjamin E.} and Rachelle Gaudet and Domenico Tortorella and Wang, {Evelyn W.} and Ploegh, {Hidde L.}",

note = "Funding Information: We acknowledge members of the Ploegh and Wiley laboratories for helpful discussions during the preparation of this manuscript. BEG is a predoctoral fellow of the Howard Hughes Medical Institute. RG is supported by a Damon Runyon-Walter Winchell fellowship. DT is supported by a Charles A King trust. EWW was supported by a National Cancer Institute (NCI) Fellowship in Cancer Biology. Figures were prepared with RIBBONS or GRASP. ",

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T1 - Virus subversion of immunity

T2 - A structural perspective

AU - Gewurz, Benjamin E.

AU - Gaudet, Rachelle

AU - Tortorella, Domenico

AU - Wang, Evelyn W.

AU - Ploegh, Hidde L.

N1 - Funding Information: We acknowledge members of the Ploegh and Wiley laboratories for helpful discussions during the preparation of this manuscript. BEG is a predoctoral fellow of the Howard Hughes Medical Institute. RG is supported by a Damon Runyon-Walter Winchell fellowship. DT is supported by a Charles A King trust. EWW was supported by a National Cancer Institute (NCI) Fellowship in Cancer Biology. Figures were prepared with RIBBONS or GRASP.

PY - 2001/8/1

Y1 - 2001/8/1

N2 - Over the past year, we have witnessed the discovery of further virus immuno-evasins - proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.

AB - Over the past year, we have witnessed the discovery of further virus immuno-evasins - proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.

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U2 - 10.1016/S0952-7915(00)00239-9

DO - 10.1016/S0952-7915(00)00239-9

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EP - 450

JO - Current Opinion in Immunology

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ER -

Virus subversion of immunity: A structural perspective

Abstract

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