Virus resistance and sensitivity in cultured human synovial cells as a possible genetic marker

L. N. Chessin; K. Hirschhorn

doi:10.1016/0014-4827(61)90070-2

Virus resistance and sensitivity in cultured human synovial cells as a possible genetic marker

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Abstract

Cells from a permanent culture established from normal human synovial tissue demonstrate an ability to take up polio virus and permit it to reproduce without any apparent cytopathic effect. A group of these cells were permitted to reproduce in the presence of polio I virus for several passages until the offspring became completely resistant to polio I virus infection. When these cells were irradiated with ultraviolet light, measurable virus uptake and reproduction re-occurred after several passages.

Original language	English
Pages (from-to)	138-144
Number of pages	7
Journal	Experimental Cell Research
Volume	23
Issue number	1
DOIs	https://doi.org/10.1016/0014-4827(61)90070-2
State	Published - Feb 1961
Externally published	Yes

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title = "Virus resistance and sensitivity in cultured human synovial cells as a possible genetic marker",

abstract = "Cells from a permanent culture established from normal human synovial tissue demonstrate an ability to take up polio virus and permit it to reproduce without any apparent cytopathic effect. A group of these cells were permitted to reproduce in the presence of polio I virus for several passages until the offspring became completely resistant to polio I virus infection. When these cells were irradiated with ultraviolet light, measurable virus uptake and reproduction re-occurred after several passages.",

author = "Chessin, {L. N.} and K. Hirschhorn",

note = "Funding Information: 1 This investigation was supported in part by research grants H-2202 from Sational Institute, U.S. Public Health Service and the American Heart Association. 2 Established investigator of the American Heart Association.",

year = "1961",

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doi = "10.1016/0014-4827(61)90070-2",

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AU - Hirschhorn, K.

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Y1 - 1961/2

N2 - Cells from a permanent culture established from normal human synovial tissue demonstrate an ability to take up polio virus and permit it to reproduce without any apparent cytopathic effect. A group of these cells were permitted to reproduce in the presence of polio I virus for several passages until the offspring became completely resistant to polio I virus infection. When these cells were irradiated with ultraviolet light, measurable virus uptake and reproduction re-occurred after several passages.

AB - Cells from a permanent culture established from normal human synovial tissue demonstrate an ability to take up polio virus and permit it to reproduce without any apparent cytopathic effect. A group of these cells were permitted to reproduce in the presence of polio I virus for several passages until the offspring became completely resistant to polio I virus infection. When these cells were irradiated with ultraviolet light, measurable virus uptake and reproduction re-occurred after several passages.

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Virus resistance and sensitivity in cultured human synovial cells as a possible genetic marker

Abstract

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