TY - JOUR
T1 - Virus load and risk of heterosexual transmission of human immunodeficiency virus and hepatitis C virus by men with hemophilia
AU - Hisada, Michie
AU - O'Brien, Thomas R.
AU - Rosenberg, Philip S.
AU - Goedert, James J.
AU - Gail, Mitchell
AU - Rabkin, Charles
AU - Kroner, Barbara
AU - Wilson, Susan
AU - Aledort, Louis
AU - Seremetes, Stephanie
AU - Eyster, Elaine
AU - Di Michele, Donna
AU - Hilgartner, Margaret
AU - Konkle, Barbara
AU - Blatt, Philip
AU - White, Gilbert
AU - Cohen, Alan
AU - Kessler, Craig
AU - Lederman, Michael
AU - Leissinger, Cindy
AU - Manco-Johnson, Marilyn
AU - Hoots, W. Keith
AU - De Moerloose, Philippe
AU - Hatzakis, Angelos
AU - Karfoulidou, Anastasia
AU - Mandalaki, Titika
AU - Schramm, Wolfgang
AU - Eichinger, Sabine
PY - 2000
Y1 - 2000
N2 - A high human immunodeficiency virus (HIV) load may increase the probability of HIV transmission by sexual contact, but the association of virus load of hepatitis C virus (HCV) with risk of HCV transmission is uncertain. HIV and HCV virus loads were examined in hemophilic men, as were risks of HIV and HCV transmission to their female partners in a hemophilia cohort in which most subjects are dually infected. A higher HIV load was associated with an increased risk of HIV transmission (odds ratio [OR], 1.31 per log10 increase in virus load). A higher HCV load was associated, although not significantly, with an increased risk of HCV transmission (OR, 1.42 per log10). HCV load was higher among dually infected men than in those infected with HCV alone (P = .001). However, much larger studies are needed to clearly show whether HIV/HCV coinfection significantly increases the risk of HCV transmission to female partners.
AB - A high human immunodeficiency virus (HIV) load may increase the probability of HIV transmission by sexual contact, but the association of virus load of hepatitis C virus (HCV) with risk of HCV transmission is uncertain. HIV and HCV virus loads were examined in hemophilic men, as were risks of HIV and HCV transmission to their female partners in a hemophilia cohort in which most subjects are dually infected. A higher HIV load was associated with an increased risk of HIV transmission (odds ratio [OR], 1.31 per log10 increase in virus load). A higher HCV load was associated, although not significantly, with an increased risk of HCV transmission (OR, 1.42 per log10). HCV load was higher among dually infected men than in those infected with HCV alone (P = .001). However, much larger studies are needed to clearly show whether HIV/HCV coinfection significantly increases the risk of HCV transmission to female partners.
UR - http://www.scopus.com/inward/record.url?scp=0034100978&partnerID=8YFLogxK
U2 - 10.1086/315396
DO - 10.1086/315396
M3 - Article
C2 - 10753732
AN - SCOPUS:0034100978
SN - 0022-1899
VL - 181
SP - 1475
EP - 1478
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 4
ER -