TY - JOUR
T1 - Virtual Functional Assessment of Coronary Stenoses Using Intravascular Ultrasound Imaging
T2 - A Proof-of-Concept Pilot Study
AU - Siogkas, Panagiotis K.
AU - Papafaklis, Michail I.
AU - Lakkas, Lampros
AU - Exarchos, Themis P.
AU - Karmpaliotis, Dimitri
AU - Ali, Ziad A.
AU - Pelosi, Gualtiero
AU - Parodi, Oberdan
AU - Katsouras, Christos S.
AU - Fotiadis, Dimitrios I.
AU - Michalis, Lampros K.
N1 - Publisher Copyright:
© 2018
PY - 2019/4
Y1 - 2019/4
N2 - Aims: We aimed to investigate the performance of virtual functional assessment of coronary stenoses using intravascular ultrasound (IVUS)-based three-dimensional (3D) coronary artery reconstruction against the invasively measured fractional flow reserve (FFR). Methods and Results: Twenty-two (22) patients with either typical symptoms of stable angina or a positive stress test, who underwent IVUS and FFR, were included in this study. Five (5) patients presented FFR values lower than the 0.80 threshold, indicating ischaemia. IVUS-based 3D reconstruction and blood flow simulation were performed and the virtual functional assessment index (vFAI) was calculated. A strong correlation between IVUS-based vFAI and FFR was observed (Spearman correlation coefficient [r s ] = 0.88, p < 0.0001). There was a small overestimation of the FFR by the IVUS-based vFAI (mean difference = 0.0196 ± 0.037; p = 0.023 for difference from zero). All cases with haemodynamically significant stenoses (FFR ≤ 0.8) were correctly categorised by the IVUS-based vFAI (vFAI ≤ 0.8). Conclusion: The proposed approach allows the complete and comprehensive assessment of coronary stenoses providing anatomic and physiologic information, pre- and post-intervention, using only an IVUS catheter without the use of a pressure wire.
AB - Aims: We aimed to investigate the performance of virtual functional assessment of coronary stenoses using intravascular ultrasound (IVUS)-based three-dimensional (3D) coronary artery reconstruction against the invasively measured fractional flow reserve (FFR). Methods and Results: Twenty-two (22) patients with either typical symptoms of stable angina or a positive stress test, who underwent IVUS and FFR, were included in this study. Five (5) patients presented FFR values lower than the 0.80 threshold, indicating ischaemia. IVUS-based 3D reconstruction and blood flow simulation were performed and the virtual functional assessment index (vFAI) was calculated. A strong correlation between IVUS-based vFAI and FFR was observed (Spearman correlation coefficient [r s ] = 0.88, p < 0.0001). There was a small overestimation of the FFR by the IVUS-based vFAI (mean difference = 0.0196 ± 0.037; p = 0.023 for difference from zero). All cases with haemodynamically significant stenoses (FFR ≤ 0.8) were correctly categorised by the IVUS-based vFAI (vFAI ≤ 0.8). Conclusion: The proposed approach allows the complete and comprehensive assessment of coronary stenoses providing anatomic and physiologic information, pre- and post-intervention, using only an IVUS catheter without the use of a pressure wire.
KW - FFR
KW - IVUS
KW - Virtual functional assessment index
UR - http://www.scopus.com/inward/record.url?scp=85048252159&partnerID=8YFLogxK
U2 - 10.1016/j.hlc.2018.02.011
DO - 10.1016/j.hlc.2018.02.011
M3 - Article
C2 - 29895487
AN - SCOPUS:85048252159
SN - 1443-9506
VL - 28
SP - e33-e36
JO - Heart Lung and Circulation
JF - Heart Lung and Circulation
IS - 4
ER -