Viral subversion of the immune system

Domenico Tortorella; Benjamin E. Gewurz; Margo H. Furman; Danny J. Schust; Hidde L. Ploegh

doi:10.1146/annurev.immunol.18.1.861

Viral subversion of the immune system

Domenico Tortorella, Benjamin E. Gewurz, Margo H. Furman, Danny J. Schust, Hidde L. Ploegh

Research output: Contribution to journal › Review article › peer-review

722 Scopus citations

Abstract

This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include targeting of pathways for major histocompatibility complex- restricted antigen presentation, apoptosis, cytokine-mediated signaling, and humoral immune responses. The continuous interactions between host and pathogens during their coevolution have shaped the immune system, but also the counter measures used by pathogens. Further study of their interactions should improve our ability to manipulate and exploit the various pathogens.

Original language	English
Pages (from-to)	861-926
Number of pages	66
Journal	Annual Review of Immunology
Volume	18
DOIs	https://doi.org/10.1146/annurev.immunol.18.1.861
State	Published - 2000
Externally published	Yes

Keywords

Antigen presentation
Apoptosis
Complement
Cytokines
Viral evasion

Access to Document

10.1146/annurev.immunol.18.1.861

Cite this

@article{e9241b80112743d69ae7a7c8fc6f46c3,

title = "Viral subversion of the immune system",

abstract = "This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include targeting of pathways for major histocompatibility complex- restricted antigen presentation, apoptosis, cytokine-mediated signaling, and humoral immune responses. The continuous interactions between host and pathogens during their coevolution have shaped the immune system, but also the counter measures used by pathogens. Further study of their interactions should improve our ability to manipulate and exploit the various pathogens.",

keywords = "Antigen presentation, Apoptosis, Complement, Cytokines, Viral evasion",

author = "Domenico Tortorella and Gewurz, {Benjamin E.} and Furman, {Margo H.} and Schust, {Danny J.} and Ploegh, {Hidde L.}",

year = "2000",

doi = "10.1146/annurev.immunol.18.1.861",

language = "English",

volume = "18",

pages = "861--926",

journal = "Annual Review of Immunology",

issn = "0732-0582",

publisher = "Annual Reviews Inc.",

}

TY - JOUR

T1 - Viral subversion of the immune system

AU - Tortorella, Domenico

AU - Gewurz, Benjamin E.

AU - Furman, Margo H.

AU - Schust, Danny J.

AU - Ploegh, Hidde L.

PY - 2000

Y1 - 2000

N2 - This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include targeting of pathways for major histocompatibility complex- restricted antigen presentation, apoptosis, cytokine-mediated signaling, and humoral immune responses. The continuous interactions between host and pathogens during their coevolution have shaped the immune system, but also the counter measures used by pathogens. Further study of their interactions should improve our ability to manipulate and exploit the various pathogens.

AB - This review describes the diverse array of pathways and molecular targets that are used by viruses to elude immune detection and destruction. These include targeting of pathways for major histocompatibility complex- restricted antigen presentation, apoptosis, cytokine-mediated signaling, and humoral immune responses. The continuous interactions between host and pathogens during their coevolution have shaped the immune system, but also the counter measures used by pathogens. Further study of their interactions should improve our ability to manipulate and exploit the various pathogens.

KW - Antigen presentation

KW - Apoptosis

KW - Complement

KW - Cytokines

KW - Viral evasion

UR - http://www.scopus.com/inward/record.url?scp=0034080319&partnerID=8YFLogxK

U2 - 10.1146/annurev.immunol.18.1.861

DO - 10.1146/annurev.immunol.18.1.861

M3 - Review article

C2 - 10837078

AN - SCOPUS:0034080319

SN - 0732-0582

VL - 18

SP - 861

EP - 926

JO - Annual Review of Immunology

JF - Annual Review of Immunology

ER -

Viral subversion of the immune system

Abstract

Keywords

Access to Document

Fingerprint

Cite this