Viral studies on amniotic fluid from fetuses with and without abnormalities detected by prenatal sonography

Boris M. Petrikovsky, Steven M. Lipson, Mark H. Kaplan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

OBJECTIVE: To study the prevalence of viruses (cytomegalovirus [CMV] adenoviruses and enteroviruses) in amniotic fluid samples from fetuses with and without anomalies detected by prenatal sonography. STUDY DESIGN: Fluid samples obtained aseptically from 474 women undergoing genetic amniocentesis at our institutions from 1995 to 1996 were stored at -20°C. Fetal anomalies (renal, central nervous system, gastrointestinal and cardiac) were detected by ultrasound in 162 of the fetuses. At a later date, the samples were retrieved, blinded, and tested by virus isolation techniques for CMV, adenoviruses and enteroviruses. Fisher's exact test was used for statistical analysis. RESULTS: The prevalence of viral isolation in amniotic fluid samples in fetuses with anomalies was 2.5% for CMV, 1.3% for adenovirus and 1.2% for enterovirus. Structurally normal fetuses had prevalences of 0.3%, 0% and 0%, respectively. CONCLUSION: The prevalence of viruses, especially CMV, appears to be higher in amniotic fluid from fetuses with sonographically detected anomalies.

Original languageEnglish
Pages (from-to)230-232
Number of pages3
JournalThe Journal of reproductive medicine
Volume48
Issue number4
StatePublished - 1 Apr 2003
Externally publishedYes

Keywords

  • Amniotic fluid
  • Cytomegalovirus infections
  • Prenatal
  • Prenatal diagnosis
  • Ultrasonography
  • Viruses

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