Viral Hepatitis Non: B, C, D and Acute and Acute on Chronic Liver Failure

Ben L. Da, Andrew Nguyen, Ali Khan, Douglas T. Dieterich

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Acute liver failure (ALF) and acute on chronic liver failure (ACLF) are two unique clinical syndromes associated with a high risk of mortality. Non-HBV/HCV/HDV viruses including the hepatotrophic viruses (HAV and HEV) and non-hepatotrophic viruses (EBV/CMV/VZV) are important causes of both syndromes. Diagnosis of ALF and ACLF relies on proper physician awareness especially in high risk populations and the correct testing in the setting of a compatible clinical picture. Prevention of certain viruses such as HAV and HEV in endemic populations with proper hygiene and vaccination is critical. Prognosis and management differs with each disease condition but includes supportive care for failing organ systems, virus directed treatment, and liver transplantation.

Original languageEnglish
Title of host publicationLiver Failure
Subtitle of host publicationAcute and Acute on Chronic
PublisherSpringer International Publishing
Number of pages32
ISBN (Electronic)9783030509835
ISBN (Print)9783030509828
StatePublished - 30 Oct 2020


  • Acute life failure
  • Acute on chronic liver failure
  • Cytomegalovirus
  • Epstein-Barr virus
  • Hepatitis A virus
  • Hepatitis E virus
  • Varicella zoster virus


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