Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

Judd F. Hultquist; Mawuena Binka; Rebecca S. Larue; Viviana Simon; Reuben S. Harris

doi:10.1128/JVI.06950-11

Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

Judd F. Hultquist, Mawuena Binka, Rebecca S. Larue, Viviana Simon, Reuben S. Harris

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by their respective lentiviral Vif proteins.

Original language	English
Pages (from-to)	2874-2877
Number of pages	4
Journal	Journal of Virology
Volume	86
Issue number	5
DOIs	https://doi.org/10.1128/JVI.06950-11
State	Published - Mar 2012

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abstract = "HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by their respective lentiviral Vif proteins.",

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AU - Hultquist, Judd F.

AU - Binka, Mawuena

AU - Larue, Rebecca S.

AU - Simon, Viviana

AU - Harris, Reuben S.

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AB - HIV-1 requires the cellular transcription factor CBFβ to stabilize its accessory protein Vif and promote APOBEC3G degradation. Here, we demonstrate that both isoforms of CBFβ allow for increased steady-state levels of Vif, enhanced APOBEC3G degradation, and increased viral infectivity. This conserved functional interaction enhances the steady-state levels of Vif proteins from multiple HIV-1 subtypes and is required for the degradation of all human and rhesus Vif-sensitive APOBEC3 proteins by their respective lentiviral Vif proteins.

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Vif proteins of human and simian immunodeficiency viruses require cellular CBFβ to degrade APOBEC3 restriction factors

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