View of K+ secretion through the apical K channel of cortical collecting duct

Wen Hui Wang

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

The apical small-conductance K+ channel plays an important role in renal K+ secretion, as evidenced by the presence of the extensive modulatory pathways. Stimulation of adenylate cyclase enhances channel activity and consequently K+ secretion. In contrast, increases in intracellular Ca2+ concentration and activation of Ca2+-dependent signal transduction pathways inhibit the K+ channel and thus decrease K+ secretion. The vasopressin-induced stimulation of K+ secretion in CCD results at least in part from cAMP-dependent signal transduction pathways. The Ca2+-dependent signal transduction pathway is responsible for modulatory coupling between Na+ pump turnover and apical K+ conductance when the Na+ pump is inhibited.

Original languageEnglish
Pages (from-to)1024-1030
Number of pages7
JournalKidney International
Volume48
Issue number4
DOIs
StatePublished - Oct 1995
Externally publishedYes

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