Vieillissement cérébral normal et maladie d'Alzheimer: Des lésions neuropathologiques à l'altération des fonctions cognitives

P. Giannakopoulos; A. S. Giannakopoulos; P. R. Hof; J. P. Michel; C. Bouras

Vieillissement cérébral normal et maladie d'Alzheimer: Des lésions neuropathologiques à l'altération des fonctions cognitives

Translated title of the contribution: Cerebral aging and Alzheimer's disease from neuropathological changes to cognitive impairment

P. Giannakopoulos, A. S. Giannakopoulos, P. R. Hof, J. P. Michel, C. Bouras

Research output: Contribution to journal › Article › peer-review

Abstract

In order to examine the patterns of lesion distribution in cerebral aging, we review the clinicopathological analysis of 147 autopsy cases including cognitively intact cases, cases with age-associated memory impairment (AAMI) and fuses wild Alzheimer's disease (AD). Regardless of cognitive status, layer II of the entorhinal cortex is involved with neurofibrillary tangle (NFT) formation in all of the cases, while the (A) field of the hippocampus and the subiculum are less consistently affected. The inferior temporal cortex (area 20) is particularly prone to develop NFT in intellectually preserved elders. Quantitatively, AAMI correlates with NFT densities in layer II of the entorhinal cortex, and clinically overt AD with NFT densities in area 20. These observations demonstrate that mesial and inferior temporal lobe structures are affected frequently in brain aging.

Translated title of the contribution	Cerebral aging and Alzheimer's disease from neuropathological changes to cognitive impairment
Original language	French
Pages (from-to)	2201-2203
Number of pages	3
Journal	Medecine et Hygiene
Volume	55
Issue number	2185
State	Published - 1997
Externally published	Yes

Cite this

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abstract = "In order to examine the patterns of lesion distribution in cerebral aging, we review the clinicopathological analysis of 147 autopsy cases including cognitively intact cases, cases with age-associated memory impairment (AAMI) and fuses wild Alzheimer's disease (AD). Regardless of cognitive status, layer II of the entorhinal cortex is involved with neurofibrillary tangle (NFT) formation in all of the cases, while the (A) field of the hippocampus and the subiculum are less consistently affected. The inferior temporal cortex (area 20) is particularly prone to develop NFT in intellectually preserved elders. Quantitatively, AAMI correlates with NFT densities in layer II of the entorhinal cortex, and clinically overt AD with NFT densities in area 20. These observations demonstrate that mesial and inferior temporal lobe structures are affected frequently in brain aging.",

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year = "1997",

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AU - Hof, P. R.

AU - Michel, J. P.

AU - Bouras, C.

PY - 1997

Y1 - 1997

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AB - In order to examine the patterns of lesion distribution in cerebral aging, we review the clinicopathological analysis of 147 autopsy cases including cognitively intact cases, cases with age-associated memory impairment (AAMI) and fuses wild Alzheimer's disease (AD). Regardless of cognitive status, layer II of the entorhinal cortex is involved with neurofibrillary tangle (NFT) formation in all of the cases, while the (A) field of the hippocampus and the subiculum are less consistently affected. The inferior temporal cortex (area 20) is particularly prone to develop NFT in intellectually preserved elders. Quantitatively, AAMI correlates with NFT densities in layer II of the entorhinal cortex, and clinically overt AD with NFT densities in area 20. These observations demonstrate that mesial and inferior temporal lobe structures are affected frequently in brain aging.

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Vieillissement cérébral normal et maladie d'Alzheimer: Des lésions neuropathologiques à l'altération des fonctions cognitives

Abstract

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