TY - JOUR
T1 - Vicious circle
T2 - Systemic autoreactivity in Ro52/TRIM21-deficient mice
AU - Bolland, Silvia
AU - Garcia-Sastre, Adolfo
PY - 2009/8/3
Y1 - 2009/8/3
N2 - Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory factors (IRFs). A new study validates the role of these common autoantigens in preventing autoimmunity. The findings reveal that injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driven by the IL-23-Th17 pathway.
AB - Dysregulated innate responses, particularly excessive activation of interferon (IFN) pathways, have been implicated in the development of autoimmune pathologies. Autoreactivity frequently targets IFN-inducible genes such as the Ro autoantigens, which ubiquitinate and inhibit interferon regulatory factors (IRFs). A new study validates the role of these common autoantigens in preventing autoimmunity. The findings reveal that injury-induced systemic autoimmune disease is exacerbated in the absence of Ro52/Trim21 and is driven by the IL-23-Th17 pathway.
UR - http://www.scopus.com/inward/record.url?scp=68149156009&partnerID=8YFLogxK
U2 - 10.1084/jem.20091507
DO - 10.1084/jem.20091507
M3 - Article
C2 - 19635865
AN - SCOPUS:68149156009
SN - 0022-1007
VL - 206
SP - 1647
EP - 1651
JO - Journal of Experimental Medicine
JF - Journal of Experimental Medicine
IS - 8
ER -